H
Hélio S. Dutra
Researcher at Federal University of Rio de Janeiro
Publications - 19
Citations - 1901
Hélio S. Dutra is an academic researcher from Federal University of Rio de Janeiro. The author has contributed to research in topics: Bone marrow & Myeloid. The author has an hindex of 14, co-authored 18 publications receiving 1867 citations.
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Journal ArticleDOI
Transendocardial, Autologous Bone Marrow Cell Transplantation for Severe, Chronic Ischemic Heart Failure
Emerson C. Perin,Hans F. Dohmann,Radovan Borojevic,Suzana A. Silva,Andre L.S. Sousa,Claudio Tinoco Mesquita,Maria Isabel D. Rossi,Antonio Carlos Carvalho,Hélio S. Dutra,Hans J.F. Dohmann,Guilherme V. Silva,Luciano Belem,Ricardo Vivacqua,Fernando Oswaldo Dias Rangel,Roberto Esporcatte,Yong-Jian Geng,William K. Vaughn,Joao A.R. Assad,Evandro Tinoco Mesquita,James T. Willerson +19 more
TL;DR: The present study demonstrates the relative safety of intramyocardial injections of bone marrow–derived stem cells in humans with severe heart failure and the potential for improving myocardial blood flow with associated enhancement of regional and global left ventricular function.
Journal ArticleDOI
Osteoblasts and bone marrow mesenchymal stromal cells control hematopoietic stem cell migration and proliferation in 3D in vitro model.
Ana Paula D. N. de Barros,Christina Maeda Takiya,Luciana Ribeiro Garzoni,Mona Lisa Leal-Ferreira,Hélio S. Dutra,Luciana B. Chiarini,Maria de Nazareth Leal de Meirelles,Radovan Borojevic,Maria Isabel D. Rossi +8 more
TL;DR: Undifferentiated and one-week osteo-induced BMSC self-assembled in a 3D spheroid and formed a microenvironment that is informative for hematopoietic progenitor cells, allowing their lodgment and controlling their proliferation.
Journal ArticleDOI
Transendocardial Autologous Bone Marrow Mononuclear Cell Injection in Ischemic Heart Failure Postmortem Anatomicopathologic and Immunohistochemical Findings
Hans F. Dohmann,Emerson C. Perin,Christina Maeda Takiya,Guilherme V. Silva,Suzana A. Silva,Andre L.S. Sousa,Claudio Tinoco Mesquita,Maria-Isabel D. Rossi,Bernardo Miguel de Oliveira Pascarelli,Isabella Mariana de Assis,Hélio S. Dutra,Joao A.R. Assad,Rodrigo V. Castello-Branco,Cantidio Drummond,Hans J.F. Dohmann,James T. Willerson,Radovan Borojevic +16 more
TL;DR: Eleven months after treatment, morphological and immunocytochemical analysis of the sites of ABMM cell injection showed no abnormal cell growth or tissue lesions and suggested that an active process of angiogenesis was present in both the fibrotic cicatricial tissue and the adjacent cardiac muscle.
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The effect of autologous concentrated bone-marrow grafting on the healing of femoral shaft non-unions after locked intramedullary nailing
João Antonio Matheus Guimarães,Maria Eugenia Leite Duarte,Marco Bernardo Cury Fernandes,Verônica Fernandes Vianna,Tito Henrique Rocha,Danielle Cabral Bonfim,Priscila Ladeira Casado,Isabel Cristina Chulvis do Val Guimarães,Luis Guillermo Coca Velarde,Hélio S. Dutra,Peter V. Giannoudis,Peter V. Giannoudis +11 more
TL;DR: The efficacy of percutaneous autologous concentrated bone marrow grafting seems to be related to the number of osteoprogenitors available in the aspirates, particularly in patients with failed femoral shaft aseptic non-union.
Journal ArticleDOI
Leishmania donovani surface glycoconjugate GP36 is the major immunogen component of the fucose-mannose ligand (FML).
TL;DR: The 36 kDa-glycoprotein was identified as the major FML antigenic fraction and designated 'GP36', and the integrity of the glycidic moiety was necessary for its antigenicity.