Andreas Popp

TL;DR: It is shown that missense point mutations in the cytoplasmic dynein heavy chain result in progressive motor neuron degeneration in heterozygous mice, and in homozygotes this is accompanied by the formation of Lewy-like inclusion bodies, thus resembling key features of human pathology.

TL;DR: IL-22 is increased in active Crohn's disease and promotes proinflammatory gene expression and IEC migration, which suggests an important function in intestinal inflammation and wound healing.

TL;DR: This mutant identifies Plcg2 as a key regulator in an autoimmune and inflammatory disease mediated by B cells and non-B, non-T haematopoietic cells and emphasizes that by distinct genetic modulation, a single point mutation can lead to a complex immunological phenotype.

TL;DR: Wang et al. as mentioned in this paper developed a formulation for pulmonary administration of siRNA to suppress SARS-CoV-2 replication in lung epithelial cells, which represented the main cellular target of viral infection in the lung.

TL;DR: In this article, it was shown that gob-4 (homologue of the XAG-2) is required for normal goblet cell function in particular mucus production.