P
Patrick Hurban
Researcher at Research Triangle Park
Publications - 9
Citations - 2127
Patrick Hurban is an academic researcher from Research Triangle Park. The author has contributed to research in topics: Gene expression profiling & Gene expression. The author has an hindex of 8, co-authored 9 publications receiving 2089 citations.
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Journal ArticleDOI
MicroRNA expression detected by oligonucleotide microarrays: System establishment and expression profiling in human tissues
Omer Barad,Eti Meiri,Amir Avniel,Ranit Aharonov,Adi Barzilai,Isaac Bentwich,Uri Einav,Shlomit Gilad,Patrick Hurban,Yael Karov,Edward K. Lobenhofer,Eilon Sharon,Yoel M. Shiboleth,Marat Shtutman,Zvi Bentwich,Paz Einat +15 more
TL;DR: The established MIR-specific oligonucleotide microarray system that enables efficient analysis of the expression of the human MIRs identified so far is established, and novel data on MIR expression in thymus, testes, and placenta is presented.
Journal ArticleDOI
Performance comparison of one-color and two-color platforms within the Microarray Quality Control (MAQC) project
Tucker A. Patterson,Edward K. Lobenhofer,Stephanie Fulmer-Smentek,Patrick J. Collins,Tzu-Ming Chu,Wenjun Bao,Hong Fang,Ernest S. Kawasaki,Janet Hager,Irina Tikhonova,Stephen J. Walker,Liang Zhang,Patrick Hurban,Francoise de Longueville,James C. Fuscoe,Weida Tong,Leming Shi,Russell D. Wolfinger +17 more
TL;DR: Cumulatively, these comparisons indicate that data quality is essentially equivalent between the one- and two-color approaches and strongly suggest that this variable need not be a primary factor in decisions regarding experimental microarray design.
Journal ArticleDOI
Standardizing global gene expression analysis between laboratories and across platforms
Theodore Bammler,Richard P. Beyer,Sanchita Bhattacharya,Gary A. Boorman,Abee L. Boyles,Blair U. Bradford,Roger E. Bumgarner,Pierre R. Bushel,Kabir Chaturvedi,Dongseok Choi,Michael L. Cunningham,Shibing Deng,Holly K. Dressman,Rickie D. Fannin,Fredrico M. Farin,Jonathan H. Freedman,Rebecca C. Fry,Angel Harper,Michael C. Humble,Patrick Hurban,Terrance J. Kavanagh,William K. Kaufmann,Kathleen F. Kerr,Li Jing,Jodi Lapidus,Michael R. Lasarev,Jianying Li,Yi-Ju Li,Edward K. Lobenhofer,Xinfang Lu,Renae L. Malek,Sean Milton,Srinivasa R. Nagalla,Jean P. O'Malley,Valerie S. Palmer,Patrick Pattee,Richard S. Paules,Charles M. Perou,Ken Phillips,Li-Xuan Qin,Yang Qiu,Sean D. Quigley,Matthew Rodland,Ivan Rusyn,Leona D. Samson,David A. Schwartz,Yan Shi,Jung Lim Shin,Stella O. Sieber,Susan H. Slifer,Marcy C. Speer,Peter S. Spencer,Dean I. Sproles,James A. Swenberg,William A. Suk,Robert C. Sullivan,Ru Tian,Raymond W. Tennant,Signe A. Todd,Charles J. Tucker,Bennett Van Houten,Brenda K. Weis,Shirley Xuan,Helmut Zarbl +63 more
TL;DR: In this paper, the authors proposed a method for standardizing global gene expression analysis between laboratories and across platforms, which can be found in Section 5.2.1.1].
Journal ArticleDOI
Rat toxicogenomic study reveals analytical consistency across microarray platforms
Lei Guo,Edward K. Lobenhofer,Charles Wang,Richard Shippy,Stephen C. Harris,Lu Zhang,Nan Mei,Tao Chen,Damir Herman,Federico Goodsaid,Patrick Hurban,K. L. Phillips,Jun Xu,Xutao Deng,Yongming Andrew Sun,Weida Tong,Yvonne P. Dragan,Leming Shi +17 more
TL;DR: The real-world toxicogenomic data set reported here showed high concordance in intersite and cross-platform comparisons and gene lists generated by fold-change ranking were more reproducible than those obtained by t-test P value or Significance Analysis of Microarrays.
Journal ArticleDOI
Profiles of Global Gene Expression in Ionizing-Radiation–Damaged Human Diploid Fibroblasts Reveal Synchronization behind the G1 Checkpoint in a G0-like State of Quiescence
Tong Zhou,Jeff W. Chou,Dennis A. Simpson,Yingchun Zhou,Thomas E. Mullen,Margarida Medeiros,Pierre R. Bushel,Richard S. Paules,Xuebin Yang,Patrick Hurban,Edward K. Lobenhofer,William K. Kaufmann +11 more
TL;DR: A highly stereotypic pattern of response to IR in human diploid fibroblasts is revealed that reflects primarily synchronization behind the G1 checkpoint but with prominent induction of additional markers of G0 quiescence such as GAS1.