H
Hemlata Dwivedi-Agnihotri
Researcher at Indian Institute of Technology Kanpur
Publications - 17
Citations - 398
Hemlata Dwivedi-Agnihotri is an academic researcher from Indian Institute of Technology Kanpur. The author has contributed to research in topics: G protein-coupled receptor & Arrestin. The author has an hindex of 6, co-authored 14 publications receiving 148 citations. Previous affiliations of Hemlata Dwivedi-Agnihotri include Indian Institutes of Technology.
Papers
More filters
Journal ArticleDOI
Molecular basis of β-arrestin coupling to formoterol-bound β 1 -adrenoceptor
Yang Lee,Tony Warne,Rony Nehmé,Shubhi Pandey,Hemlata Dwivedi-Agnihotri,Madhu Chaturvedi,Patricia C. Edwards,Javier García-Nafría,Andrew G. W. Leslie,Arun K. Shukla,Christopher G. Tate +10 more
TL;DR: In this paper, the authors determined the crystal structure of β-1-adrenoceptor coupled to β-arrestin 1 and activated by the biased agonist formoterol.
Journal ArticleDOI
Distinct phosphorylation sites in a prototypical GPCR differently orchestrate β-arrestin interaction, trafficking, and signaling
Hemlata Dwivedi-Agnihotri,Madhu Chaturvedi,Mithu Baidya,Tomasz Maciej Stepniewski,Tomasz Maciej Stepniewski,Shubhi Pandey,Jagannath Maharana,Ashish Srivastava,Natarin Caengprasath,Aylin C. Hanyaloglu,Jana Selent,Arun K. Shukla +11 more
TL;DR: It is found that several phosphorylation sites in the human vasopressin receptor (V2R), positioned either individually or in clusters, differentially contribute to βarr recruitment, trafficking, and ERK1/2 activation.
Journal ArticleDOI
Intrinsic bias at non-canonical, β-arrestin-coupled seven transmembrane receptors
Shubhi Pandey,Punita Kumari,Mithu Baidya,Ryoji Kise,Yubo Cao,Hemlata Dwivedi-Agnihotri,Ramanuj Banerjee,Xaria X. Li,Cedric S. Cui,John D. Lee,Kouki Kawakami,Jagannath Maharana,Ashutosh Ranjan,Madhu Chaturvedi,Gagan Deep Jhingan,Stéphane A. Laporte,Trent M. Woodruff,Asuka Inoue,Arun K. Shukla +18 more
TL;DR: In this paper, the decoy D6 receptor (D6R) and the complement C5a receptor subtype 2 (C5aR2) were characterized as β-arr-coupled 7TMRs.
Journal ArticleDOI
Key phosphorylation sites in GPCRs orchestrate the contribution of β-Arrestin 1 in ERK1/2 activation
Mithu Baidya,Punita Kumari,Hemlata Dwivedi-Agnihotri,Shubhi Pandey,Madhu Chaturvedi,Tomasz Maciej Stepniewski,Tomasz Maciej Stepniewski,Kouki Kawakami,Yubo Cao,Stéphane A. Laporte,Jana Selent,Asuka Inoue,Arun K. Shukla +12 more
TL;DR: Efficient engineering of a spatially positioned double‐phosphorylation‐site cluster in the bradykinin receptor (B2R) reverses the contribution of βarr1 in ERK1/2 activation from inhibitory to promotive.
Journal ArticleDOI
Biased ligands at opioid receptors: Current status and future directions
TL;DR: A summary of the current status of biased opioid ligands that target the μ- and κ-opioid receptors can be found in this paper, where the authors highlight advances in preclinical and clinical trials of some of these ligands.