John D. Lee

TL;DR: This Seminar summarises current concepts about the origin of the disease, what predisposes patients to develop the disorder, and why all cases of ALS are not the same.

TL;DR: The Concise Guide to PHARMACOLOGY 2021/22 as mentioned in this paper provides concise overviews, mostly in tabular format, of the key properties of nearly 1900 human drug targets with an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets and their ligands.

TL;DR: It is demonstrated using Nlrp3‐GFP gene knock‐in mice that ALS microglia express NLRP3, and that pathological ALS proteins activate the microglial NL RP3 inflammasome, andNLRP3 inhibition may be a potential therapeutic approach to arrest microglian neuroinflammation and ALS disease progression.

TL;DR: This review highlights the existing knowns and unknowns concerning C5aR2 and provides a timely update on recent breakthroughs which are expected to have a substantial impact on future fundamental and translational C5AR2 research.

TL;DR: A fundamental systems thinking approach is applied to the implementation of the digital twin within the process industries and a summary of process safety related opportunities and threats associated with the application of digitalized dynamic models in industry is concluded.