H
Henrik B. Rasmussen
Researcher at Copenhagen University Hospital
Publications - 90
Citations - 5250
Henrik B. Rasmussen is an academic researcher from Copenhagen University Hospital. The author has contributed to research in topics: Endogenous retrovirus & Carboxylesterase 1. The author has an hindex of 28, co-authored 90 publications receiving 4515 citations. Previous affiliations of Henrik B. Rasmussen include Roskilde University.
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Cebus apella, a nonhuman primate highly susceptible to neuroleptic side effects, carries the GLY9 dopamine receptor D3 associated with tardive dyskinesia in humans.
TL;DR: The Cebus apella monkey is the favored animal model to study TD and other EPS because of its high susceptibility to side effects of neuroleptics, and the sequence of the DRD3 gene in this species was determined and compared with that of humans.
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The Pharmacokinetics of Enalapril in Relation to CES1 Genotype in Healthy Danish Volunteers.
Claus Stage,Gesche Jürgens,Louise Schow Guski,Ragnar Thomsen,Ditte Bjerre,Laura Ferrero-Miliani,Yassine Kamal Lyauk,Henrik B. Rasmussen,Kim Dalhoff +8 more
TL;DR: In conclusion, none of the selected variations of CES1 had a clinically relevant impact on the metabolism of enalapril.
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Effect of Routine Cytochrome P450 2D6 and 2C19 Genotyping on Antipsychotic Drug Persistence in Patients With Schizophrenia: A Randomized Clinical Trial.
Gesche Jürgens,Stig Andersen,Henrik B. Rasmussen,Thomas Werge,Heidi Dorthe Jensen,Benjamin Skov Kaas-Hansen,Merete Nordentoft +6 more
TL;DR: The results of this randomized clinical trial do not support routine CYP testing in patients with schizophrenia, and primary outcome was antipsychotic drug persistence, ie, days to first modification of the initial treatment.
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Pharmacometabolomics Informs About Pharmacokinetic Profile of Methylphenidate.
Rima Kaddurah-Daouk,Thomas Hankemeier,Elizabeth H. Scholl,Rebecca Baillie,Amy C. Harms,Claus Stage,Kim Dalhoff,Gesche Jűrgens,Olivier Taboureau,Grace Shema Nzabonimpa,Alison A. Motsinger-Reif,Ragnar Thomsen,Kristian Linnet,Henrik B. Rasmussen,Henrik B. Rasmussen +14 more
TL;DR: In silico analysis suggested that bile acid inhibition of CES1 involved both binding to the active and superficial sites of the enzyme and suggested lipids to regulate or be regulated by this enzyme.
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Population Pharmacokinetics of Methylphenidate in Healthy Adults Emphasizing Novel and Known Effects of Several Carboxylesterase 1 (CES1) Variants.
Yassine Kamal Lyauk,Claus Stage,Troels K Bergmann,L Ferrero-Milliani,Ditte Bjerre,Ragnar Thomsen,Kim Peder Dalhoff,Henrik B. Rasmussen,Gesche Jürgens +8 more
TL;DR: Assessment of the independent and combined effect of CES1 covariates identified several specific risk factors that may result in severely increased d‐MPH plasma exposure.