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Alison A. Motsinger-Reif
Researcher at National Institutes of Health
Publications - 215
Citations - 6350
Alison A. Motsinger-Reif is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Medicine & Genome-wide association study. The author has an hindex of 39, co-authored 193 publications receiving 4895 citations. Previous affiliations of Alison A. Motsinger-Reif include North Carolina State University & Duke University.
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Journal ArticleDOI
Warfarin pharmacogenetics: a single VKORC1 polymorphism is predictive of dose across 3 racial groups
Nita A. Limdi,Mia Wadelius,Larisa H. Cavallari,Niclas Eriksson,Dana C. Crawford,Ming Ta Michael Lee,Chien-Hsiun Chen,Alison A. Motsinger-Reif,Hersh Sagreiya,Nianjun Liu,Alan H.B. Wu,Brian F. Gage,Andrea L. Jorgensen,Munir Pirmohamed,Jae-Gook Shin,Guilherme Suarez-Kurtz,Stephen E. Kimmel,Julie A. Johnson,Teri E. Klein,Michael J. Wagner +19 more
TL;DR: Clinicians should recognize that, although at a population level, the contribution of VKORC1 toward dose requirements is higher in whites than in nonwhites; genotype predicts similar dose requirements across racial groups.
Journal ArticleDOI
Altered bile acid profile associates with cognitive impairment in Alzheimer's disease-An emerging role for gut microbiome.
Siamak Mahmoudiandehkordi,Matthias Arnold,Kwangsik Nho,Shahzad Ahmad,Wei Jia,Wei Jia,Guoxiang Xie,Gregory Louie,Alexandra Kueider-Paisley,M. Arthur Moseley,J. Will Thompson,Lisa St John Williams,Jessica D. Tenenbaum,Colette Blach,Rebecca Baillie,Xianlin Han,Sudeepa Bhattacharyya,Jon B. Toledo,Simon Schafferer,Sebastian Klein,Therese Koal,Shannon L. Risacher,Mitchel A. Kling,Alison A. Motsinger-Reif,Daniel M. Rotroff,John Jack,Thomas Hankemeier,David A. Bennett,Philip L. De Jager,John Q. Trojanowski,Leslie M. Shaw,Michael W. Weiner,P. Murali Doraiswamy,Cornelia M. van Duijn,Andrew J. Saykin,Gabi Kastenmüller,Rima Kaddurah-Daouk +36 more
TL;DR: This data indicates that BAs, products of cholesterol metabolism and clearance, are produced in the liver and are further metabolized by gut bacteria and seem dysregulated in Alzheimer's disease (AD).
Journal ArticleDOI
Metabolic network failures in Alzheimer's disease: A biochemical road map
Jon B. Toledo,Jon B. Toledo,Matthias Arnold,Gabi Kastenmüller,Rui Chang,Rebecca Baillie,Xianlin Han,Madhav Thambisetty,Jessica D. Tenenbaum,Karsten Suhre,J. Will Thompson,Lisa St. John-Williams,Siamak Mahmoudiandehkordi,Daniel M. Rotroff,John Jack,Alison A. Motsinger-Reif,Shannon L. Risacher,Colette Blach,Joseph E. Lucas,Tyler Massaro,Gregory Louie,Hongjie Zhu,Guido Dallmann,Kristaps Klavins,Therese Koal,Sungeun Kim,Kwangsik Nho,Li Shen,Ramon Casanova,Sudhir Varma,Cristina Legido-Quigley,M. Arthur Moseley,Kuixi Zhu,Marc Henrion,Sven J. van der Lee,Amy C. Harms,Ayse Demirkan,Thomas Hankemeier,Thomas Hankemeier,Cornelia M. van Duijn,Cornelia M. van Duijn,John Q. Trojanowski,Leslie M. Shaw,Andrew J. Saykin,Michael W. Weiner,P. Murali Doraiswamy,Rima Kaddurah-Daouk +46 more
TL;DR: This article used metabolomics as a global biochemical approach to identify peripheral metabolic changes in AD patients and correlate them to cerebrospinal fluid pathology markers, imaging features, and cognitive performance.
Journal ArticleDOI
An Introduction to Terminology and Methodology of Chemical Synergy-Perspectives from Across Disciplines.
TL;DR: The various terminology surrounding the idea of synergy is discussed, providing a comprehensive list of terms defined across numerous disciplines, including the two most prominent reference models for describing additive interactions: Loewe Additivity and Bliss Independence.
Journal ArticleDOI
Alterations in metabolic pathways and networks in Alzheimer’s disease
Rima Kaddurah-Daouk,Hongjie Zhu,Swati Sharma,M Bogdanov,M Bogdanov,Steve Rozen,Wayne R. Matson,Noffisat O Oki,Alison A. Motsinger-Reif,Erik Churchill,Zhengdeng Lei,Dina Appleby,Mitchel A. Kling,John Q. Trojanowski,P. M. Doraiswamy,Steven E. Arnold +15 more
TL;DR: It is indicated that MCI and AD are associated with an overlapping pattern of perturbations in tryptophan, tyrosine, MET and purine pathways, and suggest that profound biochemical alterations are linked to abnormal Ab42 and tau metabolism.