Carol A. Vandenberg

TL;DR: An overview of the molecular relationships among the voltage-gated potassium channels and a standard nomenclature for them is derived from the IUPHAR Compendium of Voltage-Gated Ion Channels as mentioned in this paper.

TL;DR: The mechanism of rectification of the inwardly rectifying potassium channel was examined with single-channel recording techniques in isolated ventricular myocytes from adult guinea pig heart to suggest that rectification is due to internal block by Mg2+, possibly the result of rapid block of the open channel.

TL;DR: Since the initial cDNA cloning of the first inward rectifiers Kir1.1 and Kir2.1 in 1993, a succession of new members of this family have been identified, including the G protein-coupled Kir3 and the ATP-sensitive Kir6, which play an important physiological role in the nervous system.

TL;DR: It is suggested that Kir2 channels associate with protein complexes that may be important to target and traffic channels to specific subcellular locations, as well as anchor and stabilize channels in the plasma membrane.

TL;DR: Sodium channel gating behavior was modeled with Markovian models fitted to currents from the cut-open squid giant axon in the absence of divalent cations, finding rates of activation and inactivation are generally slower than activation or deactivation rates and show little or no voltage dependence.