R
Ryan J. Buus
Researcher at University of North Carolina at Chapel Hill
Publications - 20
Citations - 2300
Ryan J. Buus is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: Quantitative trait locus & Allele. The author has an hindex of 14, co-authored 20 publications receiving 2051 citations. Previous affiliations of Ryan J. Buus include University of Minnesota & Veterans Health Administration.
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Journal ArticleDOI
The genome architecture of the collaborative cross mouse genetic reference population
Fuad A. Iraqi,Mustafa Mahajne,Yasser Salaymah,Hani Sandovski,Hanna Tayem,Karin Vered,Lois Balmer,Michael R. Hall,Glynn Manship,Grant Morahan,Ken Pettit,Jeremy Scholten,Kathryn Tweedie,Andrew Wallace,Lakshini Weerasekera,James Cleak,Caroline Durrant,Leo Goodstadt,Richard Mott,Binnaz Yalcin,David L. Aylor,Ralph S. Baric,Timothy A. Bell,Katharine M. Bendt,J. Brennan,Jackie D. Brooks,Ryan J. Buus,James J. Crowley,John D. Calaway,Mark Calaway,Agnieszka Cholka,David B. Darr,John P. Didion,Amy Dorman,Eric T. Everett,Martin T. Ferris,Wendy Foulds Mathes,Chen Ping Fu,Terry J. Gooch,Summer G. Goodson,Lisa E. Gralinski,Stephanie D. Hansen,Mark T. Heise,Jane Hoel,Kunjie Hua,Mayanga C. Kapita,Seunggeun Lee,Alan B. Lenarcic,Eric Yi Liu,Hedi Liu,Leonard McMillan,Terry Magnuson,Kenneth F. Manly,Darla R. Miller,Deborah A. O'Brien,Fanny Odet,Isa Kemal Pakatci,Wenqi Pan,Fernando Pardo-Manuel de Villena,Charles M. Perou,Daniel Pomp,Corey R. Quackenbush,Nashiya N. Robinson,Norman E. Sharpless,Ginger D. Shaw,Jason S. Spence,Patrick F. Sullivan,Wei Sun,Lisa M. Tarantino,William Valdar,Jeremy Wang,Wei Wang,Catherine E. Welsh,Alan C. Whitmore,Tim Wiltshire,Fred A. Wright,Yuying Xie,Zaining Yun,Vasyl Zhabotynsky,Zhaojun Zhang,Fei Zou,Christine L. Powell,Jill Steigerwalt,David W. Threadgill,Elissa J. Chesler,Gary A. Churchill,Daniel M. Gatti,Ron Korstanje,Karen L. Svenson,Francis S. Collins,Nigel P.S. Crawford,Kent W. Hunter,N. Samir,P. Kelada,Bailey C.E. Peck,Karlyne M. Reilly,Urraca Tavarez,Daniel Bottomly,Robert Hitzeman,Shannon K. McWeeney,Jeffrey A. Frelinger,Harsha Krovi,Jason Phillippi,Richard A. Spritz,Lauri D. Aicher,Michael G. Katze,Elizabeth Rosenzweig,Ariel Shusterman,Aysar Nashef,Ervin I. Weiss,Yael Houri-Haddad,Morris Soller,Robert W. Williams,Klaus Schughart,Hyuna Yang,John E. French,Andrew K. Benson,Jaehyoung Kim,Ryan Legge,Soo Jen Low,Fangrui Ma,Inés Martínez,Jens Walter,Karl W. Broman,Benedikt Hallgrímsson,Ophir D. Klein,George M. Weinstock,Wesley C. Warren,Yvana V. Yang,David A. Schwartz +129 more
TL;DR: The Collaborative Cross Consortium reports here on the development of a unique genetic resource population, a multiparental recombinant inbred panel derived from eight laboratory mouse inbred strains, which shows that founder haplotypes are inherited at the expected frequency.
Journal ArticleDOI
Subspecific origin and haplotype diversity in the laboratory mouse
Hyuna Yang,Jeremy Wang,John P. Didion,Ryan J. Buus,Timothy A. Bell,Catherine E. Welsh,Franãois Bonhomme,Alex Hon Tsen Yu,Michael W. Nachman,Jaroslav Piálek,Priscilla K. Tucker,Pierre Boursot,Leonard McMillan,Gary A. Churchill,Fernando Pardo-Manuel de Villena +14 more
TL;DR: A genome-wide, high-resolution map of the phylogenetic origin of the genome of most extant laboratory mouse inbred strains is provided, based on the genotypes of wild-caught mice from three subspecies of Mus musculus.
Journal ArticleDOI
Genetic analysis of complex traits in the emerging Collaborative Cross
David L. Aylor,William Valdar,Wendy Foulds-Mathes,Ryan J. Buus,Ricardo A. Verdugo,Ralph S. Baric,Martin T. Ferris,Jeffrey A. Frelinger,Mark T. Heise,Matthew B. Frieman,Lisa E. Gralinski,Timothy A. Bell,John D. Didion,Kunjie Hua,Derrick L. Nehrenberg,Christine L. Powell,Jill Steigerwalt,Yuying Xie,Samir N. P. Kelada,Francis S. Collins,Ivana V. Yang,David A. Schwartz,Lisa A. Branstetter,Elissa J. Chesler,Darla R. Miller,Jason S. Spence,Eric Yi Liu,Leonard McMillan,Abhishek Sarkar,Jeremy Wang,Wei Wang,Qi Zhang,Karl W. Broman,Ron Korstanje,Caroline Durrant,Richard Mott,Fuad A. Iraqi,Daniel Pomp,David W. Threadgill,Fernando Pardo-Manuel de Villena,Gary A. Churchill +40 more
TL;DR: It is demonstrated that the genetic diversity of the CC, which derives from random mixing of eight founder strains, results in high phenotypic diversity and enhances the ability to map causative loci underlying complex disease-related traits.
Journal ArticleDOI
Analyses of allele-specific gene expression in highly divergent mouse crosses identifies pervasive allelic imbalance
James J. Crowley,Vasyl Zhabotynsky,Wei Sun,Shunping Huang,Isa Kemal Pakatci,Yunjung Kim,Jeremy Wang,Andrew P. Morgan,John D. Calaway,David L. Aylor,Zaining Yun,Timothy A. Bell,Ryan J. Buus,Mark Calaway,John P. Didion,Terry J. Gooch,Stephanie D. Hansen,Nashiya N. Robinson,Ginger D. Shaw,Jason S. Spence,Corey R. Quackenbush,Cordelia J. Barrick,Randal J. Nonneman,KyungSu Kim,James G. Xenakis,Yuying Xie,William Valdar,Alan B. Lenarcic,Wei Wang,Catherine E. Welsh,Chen Ping Fu,Zhaojun Zhang,James Holt,Zhishan Guo,David W. Threadgill,Lisa M. Tarantino,Darla R. Miller,Fei Zou,Leonard McMillan,Patrick F. Sullivan,Fernando Pardo-Manuel de Villena +40 more
TL;DR: It is concluded that, as with humans, pervasive regulatory variation influences complex genetic traits in mice and provide a new resource toward understanding the genetic control of transcription in mammals.
Journal ArticleDOI
Modeling host genetic regulation of influenza pathogenesis in the collaborative cross.
Martin T. Ferris,David L. Aylor,Daniel Bottomly,Alan C. Whitmore,Lauri D. Aicher,Timothy A. Bell,Birgit G. Bradel-Tretheway,Janine T. Bryan,Ryan J. Buus,Lisa E. Gralinski,Bart L. Haagmans,Leonard McMillan,Darla R. Miller,Elizabeth Rosenzweig,William Valdar,Jeremy Wang,Gary A. Churchill,David W. Threadgill,Shannon K. McWeeney,Michael G. Katze,Fernando Pardo-Manuel de Villena,Ralph S. Baric,Ralph S. Baric,Mark T. Heise +23 more
TL;DR: To identify how host genetic polymorphisms contribute to the observed variation in disease, quantitative trait loci (QTL) mapping was conducted and several QTL contributing to specific aspects of the host response including virus-induced weight loss, titer, pulmonary edema, neutrophil recruitment to the airways, and transcriptional expression were identified.