Hideki Iwakabe

TL;DR: Blot and in situ hybridization analyses indicated that mGluR6 mRNA is restrictedly expressed in the inner nuclear layer of the retina where ON-bipolar cells are distributed, and the physiological role of this receptor subtype in the visual system is discussed.

TL;DR: The results demonstrate that mGluR6 is essential in synaptic transmission to the ON bipolar cell and that the OFF response provides an important means for transmitting visual information.

TL;DR: It is demonstrated that the mGluR6 5′ upstream genomic sequence is capable of directing a cell-specific and developmentally regulated expression of mGlamR6 in ON-type bipolar cells and supports the view that mGLUR6 is responsible for ON responses in both the rod and cone systems.

TL;DR: It is demonstrated that mGluR6 contributes to discrimination of visual contrasts and markedly reduces the sensitivity of pupillary responses to light stimulus and severely impairs the ability to drive optokinetic nystagmus in response to visual contrasts.

TL;DR: It is proposed that the transcriptional response of CREB to light stimulation in rod bipolar cells is regulated via mGluR6, and this leads to the theory that CREB-IR and c-fos gene expression in the PKC alpha positive rods bipolar cells were lost in mice lacking metabotropic glutamate receptor 6.