H
Hideki Nakano
Researcher at Toho University
Publications - 33
Citations - 4412
Hideki Nakano is an academic researcher from Toho University. The author has contributed to research in topics: T cell & Antigen. The author has an hindex of 19, co-authored 28 publications receiving 4256 citations.
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Journal ArticleDOI
Mice Lacking Expression of Secondary Lymphoid Organ Chemokine Have Defects in Lymphocyte Homing and Dendritic Cell Localization
Michael D. Gunn,Shigeru Kyuwa,Carmen Tam,Terutaka Kakiuchi,Akio Matsuzawa,Lewis T. Williams,Hideki Nakano +6 more
TL;DR: It is suggested that the abnormalities in plt mice are due to a genetic defect in the expression of SLC and that SLC mediates the entry of naive T cells and antigen-stimulated DCs into the T cell zones of secondary lymphoid organs.
Journal ArticleDOI
Balanced responsiveness to chemoattractants from adjacent zones determines B-cell position.
Karin Reif,Eric H. Ekland,Lars Ohl,Hideki Nakano,Martin Lipp,Reinhold Förster,Jason G. Cyster +6 more
TL;DR: The mechanism of B-cell relocalization in response to antigen is defined, and it is established that cell position in vivo can be determined by the balance of responsiveness to chemoattractants made in separate but adjacent zones.
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The Cc Chemokine Thymus-Derived Chemotactic Agent 4 (Tca-4, Secondary Lymphoid Tissue Chemokine, 6ckine, Exodus-2) Triggers Lymphocyte Function–Associated Antigen 1–Mediated Arrest of Rolling T Lymphocytes in Peripheral Lymph Node High Endothelial Venules
Jens V. Stein,Antal Rot,Yi Luo,Manjunath Narasimhaswamy,Hideki Nakano,Michael D. Gunn,Akio Matsuzawa,Elizabeth J. Quackenbush,Martin E. Dorf,Ulrich H. von Andrian +9 more
TL;DR: It is concluded that TCA-4 is both required and sufficient for LFA-1 activation on rolling T cells in PLN HEVs, which highlights a hitherto undocumented role for chemokines contained in afferent lymph, which may modulate leukocyte recruitment in draining PLNs.
Journal ArticleDOI
CCR2+ monocyte-derived dendritic cells and exudate macrophages produce influenza-induced pulmonary immune pathology and mortality.
TL;DR: It is concluded that C CR2+ monocyte-derived cells are the predominant cause of immune pathology during influenza infection and that such pathology is markedly abrogated in the absence of CCR2.
Journal ArticleDOI
CCR7 Signals Are Essential for Cortex–Medulla Migration of Developing Thymocytes
Tomoo Ueno,Fumi Saito,Daniel H.D. Gray,Sachiyo Kuse,Kunio Hieshima,Hideki Nakano,Terutaka Kakiuchi,Martin Lipp,Richard L. Boyd,Yousuke Takahama +9 more
TL;DR: It is shown that in mice deficient for CCR7 or its ligands mature single-positive thymocytes are arrested in the cortex and do not accumulate in the medulla, indicating that CCR 7 signals are essential for the migration of positively selectedThymocytes from the cortex to the medullary region of the thymus.