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Elizabeth J. Quackenbush
Researcher at Harvard University
Publications - 21
Citations - 3388
Elizabeth J. Quackenbush is an academic researcher from Harvard University. The author has contributed to research in topics: Eotaxin & Lymphocyte. The author has an hindex of 16, co-authored 21 publications receiving 3247 citations. Previous affiliations of Elizabeth J. Quackenbush include Merck & Co. & National Institutes of Health.
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Journal ArticleDOI
Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists.
Suzanne M. Mandala,Richard Hajdu,James D. Bergstrom,Elizabeth J. Quackenbush,Jenny Xie,James A. Milligan,Rosemary A. Thornton,Gan-Ju Shei,Deborah Card,CarolAnn Keohane,Mark Rosenbach,Jeffrey J. Hale,Christopher L. Lynch,Kathleen M. Rupprecht,William H. Parsons,Hugh Rosen +15 more
TL;DR: It is shown that lymphocyte trafficking is altered by the lysophospholipid sphingosine-1-phosphate (S1P) and by a phosphoryl metabolites of the immunosuppressive agent FTY720.
Journal ArticleDOI
The Cc Chemokine Thymus-Derived Chemotactic Agent 4 (Tca-4, Secondary Lymphoid Tissue Chemokine, 6ckine, Exodus-2) Triggers Lymphocyte Function–Associated Antigen 1–Mediated Arrest of Rolling T Lymphocytes in Peripheral Lymph Node High Endothelial Venules
Jens V. Stein,Antal Rot,Yi Luo,Manjunath Narasimhaswamy,Hideki Nakano,Michael D. Gunn,Akio Matsuzawa,Elizabeth J. Quackenbush,Martin E. Dorf,Ulrich H. von Andrian +9 more
TL;DR: It is concluded that TCA-4 is both required and sufficient for LFA-1 activation on rolling T cells in PLN HEVs, which highlights a hitherto undocumented role for chemokines contained in afferent lymph, which may modulate leukocyte recruitment in draining PLNs.
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Specialized Contributions by α(1,3)-Fucosyltransferase-IV and FucT-VII during Leukocyte Rolling in Dermal Microvessels
Wolfgang Weninger,Laurien H. Ulfman,Guiying Cheng,Natalia Souchkova,Elizabeth J. Quackenbush,John B. Lowe,Ulrich H. von Andrian +6 more
TL;DR: A role for FucT-IV is demonstrated in selectin-dependent adhesion and it is suggested that the endothelial selectins and FucTs have distinct but overlapping functions in the immunosurveillance of the skin.
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Discovery of Potent 3,5-Diphenyl-1,2,4-oxadiazole Sphingosine-1-phosphate-1 (S1P1) Receptor Agonists with Exceptional Selectivity against S1P2 and S1P3
Zhen Li,Weirong Chen,Jeffrey J. Hale,Christopher L. Lynch,Sander G. Mills,Richard Hajdu,Carol Ann Keohane,Mark Rosenbach,James A. Milligan,Gan-Ju Shei,Gary L. Chrebet,Stephen A. Parent,Bergstrom James D,Deborah Card,Michael J. Forrest,Elizabeth J. Quackenbush,L. Alexandra Wickham,Hugo M. Vargas,Rose M. Evans,Hugh Rosen,Suzanne M. Mandala +20 more
TL;DR: Analogue 26 has an excellent pharmacokinetics profile in the rat and dog and is efficacious in a rat skin transplant model, indicating that S1P3 receptor agonism is not a component of immunosuppressive efficacy.
Journal Article
Identification of a new mouse beta-chemokine, thymus-derived chemotactic agent 4, with activity on T lymphocytes and mesangial cells.
Shigeyuki Tanabe,Zhijian Lu,Yi Luo,Elizabeth J. Quackenbush,Michael A. Berman,Lisa A. Collins-Racie,S Mi,Christina R. Reilly,David Lo,Kenneth Jacobs,Martin E. Dorf +10 more
TL;DR: Competitive binding studies with a SV40-transformed mouse mesangial cell line demonstrated that other murine beta-chemokines do not compete for TCA4 binding, and the potential role of this novel chemokine in facilitating normal lymphocyte traffic is discussed.