H
Hideyuki Sasaki
Researcher at Johns Hopkins University School of Medicine
Publications - 13
Citations - 769
Hideyuki Sasaki is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Heart failure & Cardioprotection. The author has an hindex of 9, co-authored 13 publications receiving 697 citations. Previous affiliations of Hideyuki Sasaki include Johns Hopkins University & Osaka University.
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Journal ArticleDOI
Metformin prevents progression of heart failure in dogs: role of AMP-activated protein kinase.
Hideyuki Sasaki,Hiroshi Asanuma,Masashi Fujita,Hiroyuki Takahama,Masakatsu Wakeno,Shin Ito,Akiko Ogai,Masanori Asakura,Jiyoong Kim,Tetsuo Minamino,Seiji Takashima,Shoji Sanada,Masaru Sugimachi,Kazuo Komamura,Naoki Mochizuki,Masafumi Kitakaze +15 more
TL;DR: Metformin attenuated oxidative stress–induced cardiomyocyte apoptosis and prevented the progression of heart failure in dogs, along with activation of AMPK, suggesting metformin may be a potential new therapy for heart failure.
Journal ArticleDOI
Prolonged transient acidosis during early reperfusion contributes to the cardioprotective effects of postconditioning.
Masashi Fujita,Hiroshi Asanuma,Akio Hirata,Masakatsu Wakeno,Hiroyuki Takahama,Hideyuki Sasaki,Jiyoong Kim,Seiji Takashima,Osamu Tsukamoto,Tetsuo Minamino,Yoshiro Shinozaki,Hitonobu Tomoike,Masatsugu Hori,Masafumi Kitakaze +13 more
TL;DR: Postconditioning mediates its cardioprotective effects possibly via prolonged transient acidosis during the early reperfusion phase with the activation of Akt and ERK.
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Prolonged Targeting of Ischemic/Reperfused Myocardium by Liposomal Adenosine Augments Cardioprotection in Rats
Hiroyuki Takahama,Tetsuo Minamino,Hiroshi Asanuma,Masashi Fujita,Tomohiro Asai,Masakatsu Wakeno,Hideyuki Sasaki,Hiroshi Kikuchi,Kouichi Hashimoto,Naoto Oku,Masanori Asakura,Jiyoong Kim,Seiji Takashima,Kazuo Komamura,Masaru Sugimachi,Naoki Mochizuki,Masafumi Kitakaze +16 more
TL;DR: An infusion as PEGylated liposomes augmented the cardioprotective effects of adenosine against ischemia/reperfusion injury and reduced its unfavorable hemodynamic effects.
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PKA rapidly enhances proteasome assembly and activity in in vivo canine hearts
Mitsutoshi Asai,Osamu Tsukamoto,Tetsuo Minamino,Hiroshi Asanuma,Masashi Fujita,Yoshihiro Asano,Hiroyuki Takahama,Hideyuki Sasaki,Shuichiro Higo,Masanori Asakura,Seiji Takashima,Masatsugu Hori,Masafumi Kitakaze +12 more
TL;DR: Findings indicate that PKA rapidly enhances proteasome assembly and activity in in vivo hearts.
Journal ArticleDOI
PDE5 inhibitor efficacy is estrogen dependent in female heart disease
Hideyuki Sasaki,Takahiro Nagayama,Robert M. Blanton,Kinya Seo,Manling Zhang,Guangshuo Zhu,Dong I. Lee,Djahida Bedja,Steven Hsu,Osamu Tsukamoto,Seiji Takashima,Masafumi Kitakaze,Michael E. Mendelsohn,Richard H. Karas,David A. Kass,Eiki Takimoto,Eiki Takimoto +16 more
TL;DR: The results support the importance of sex differences in the use of PDE5 inhibitors for treating heart disease and the critical role of estrogen status when these agents are used in females.