Prolonged Targeting of Ischemic/Reperfused Myocardium by Liposomal Adenosine Augments Cardioprotection in Rats
Hiroyuki Takahama,Tetsuo Minamino,Hiroshi Asanuma,Masashi Fujita,Tomohiro Asai,Masakatsu Wakeno,Hideyuki Sasaki,Hiroshi Kikuchi,Kouichi Hashimoto,Naoto Oku,Masanori Asakura,Jiyoong Kim,Seiji Takashima,Kazuo Komamura,Masaru Sugimachi,Naoki Mochizuki,Masafumi Kitakaze +16 more
TLDR
An infusion as PEGylated liposomes augmented the cardioprotective effects of adenosine against ischemia/reperfusion injury and reduced its unfavorable hemodynamic effects.About:
This article is published in Journal of the American College of Cardiology.The article was published on 2009-02-24 and is currently open access. It has received 102 citations till now. The article focuses on the topics: Adenosine & Cardioprotection.read more
Citations
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ER stress in cardiovascular disease.
TL;DR: The endoplasmic reticulum is recognized as a vitally important organelle that can decide cell survival or death and the UPR and ER-initiated apoptosis are implicated in the pathophysiology of various cardiovascular diseases.
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Endoplasmic Reticulum Stress As a Therapeutic Target in Cardiovascular Disease
TL;DR: Recent progress in understanding UPR signaling in cardiovascular disease and its related therapeutic potential is summarized and the most promising molecules to be investigated as targets for cardiovascular diseases are summarized.
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Pathophysiology of myocardial reperfusion injury: preconditioning, postconditioning, and translational aspects of protective measures
TL;DR: The idea of ischemic postconditioning with a cardioprotective potential has been discovered and established, making it possible to apply this knowledge in the clinical setting after ischemia-reperfusion insult, as well as subsequent adverse outcomes by modulation of subcellular signaling mechanisms (especially mitochondrial function).
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Perspectives and opportunities for nanomedicine in the management of atherosclerosis
TL;DR: This Review elaborates on nanoparticle-targeting concepts in Atherosclerotic disease, provides an overview of the use of nanomedicine in atherosclerosis, and discusses potential future applications and clinical benefits.
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Targeted therapy in chronic diseases using nanomaterial-based drug delivery vehicles
TL;DR: The advantages of various drug delivery vehicles are discussed for better understanding of their utility in terms of current medical needs and the application of a wide range of nanomedicines is also described in the context of major chronic diseases.
References
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Sterically stabilized liposomes: improvements in pharmacokinetics and antitumor therapeutic efficacy.
Demetrios Papahadjopoulos,Theresa M. Allen,Alberto Gabizon,E Mayhew,Katherine K. Matthay,Shi Kun Huang,Karim Lee,M C Woodle,D D Lasic,C Redemann +9 more
TL;DR: Liposome formulations incorporating a synthetic polyethylene glycol-derivatized phospholipid can produce a large increase in the pharmacological efficacy of encapsulated antitumor drugs and have expanded considerably the prospects of liposomes as an effective carrier system for a variety of pharmacologically active macromolecules.
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A randomized, double-blinded, placebo-controlled multicenter trial of adenosine as an adjunct to reperfusion in the treatment of acute myocardial infarction (AMISTAD-II)
TL;DR: Clinical outcomes in patients with STEMI undergoing reperfusion therapy were not significantly improved with adenosine, although infarct size was reduced with the 70-microg/kg/min adenosines infusion, a finding that correlated with fewer adverse clinical events.
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Adenosine as an adjunct to thrombolytic therapy for acute myocardial infarction: Results of a multicenter, randomized, placebo-controlled trial: the Acute Myocardial Infarction STudy of ADenosine (AMISTAD) Trial
Kenneth W. Mahaffey,Joseph A. Puma,N.Alejandro Barbagelata,Marcelo F. DiCarli,Massoud A. Leesar,Kevin F. Browne,Paul R. Eisenberg,Roberto Bolli,A.Cecilia Casas,Victor Molina-Viamonte,Cesare Orlandi,Roger Blevins,Raymond J. Gibbons,Robert M. Califf,Christopher B. Granger +14 more
TL;DR: The AMISTAD trial as discussed by the authors was designed to test the hypothesis that adenosine as an adjunct to thrombolysis would reduce myocardial infarct, and the results showed that the hypothesis was true.
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Adenosine, adenosine receptors and myocardial protection: an updated overview.
Kanigula Mubagwa,Willem Flameng +1 more
TL;DR: Adenosine (Ado) accumulates in tissues under metabolic stress and has been tested as a protective agent in clinical interventions such as PTCA, CABG and tissue preservation, and was found to enhance the post-ischemic recovery of function.
Journal ArticleDOI
Doxorubicin in sterically stabilized liposomes
TL;DR: Improved liposome stability and drug retention significantly increase the anticancer activity of encapsulated doxorubicin (Doxil), enhancing the effectiveness of chemotherapy and potentially reducing its toxicity.