H
Hilary A. Kenny
Researcher at University of Chicago
Publications - 44
Citations - 5349
Hilary A. Kenny is an academic researcher from University of Chicago. The author has contributed to research in topics: Ovarian cancer & Metastasis. The author has an hindex of 24, co-authored 43 publications receiving 4275 citations. Previous affiliations of Hilary A. Kenny include Northwestern University.
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Journal ArticleDOI
Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth
Kristin M Nieman,Hilary A. Kenny,Carla Penicka,Andras Ladanyi,Rebecca Buell-Gutbrod,Marion Zillhardt,Iris L. Romero,Mark S. Carey,Gordon B. Mills,Gökhan S. Hotamisligil,S. Diane Yamada,Marcus E. Peter,Katja Gwin,Ernst Lengyel +13 more
TL;DR: It is shown that primary human omental adipocytes promote homing, migration and invasion of ovarian cancer cells, and that adipokines including interleukin-8 (IL-8) mediate these activities, and adipocytes provide fatty acids for rapid tumor growth.
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Loss of E-Cadherin Promotes Ovarian Cancer Metastasis via α5-Integrin, which Is a Therapeutic Target
Kenjiro Sawada,Anirban K. Mitra,A. Reza Radjabi,Vinay Bhaskar,Emily O. Kistner,Maria Tretiakova,Sujatha Jagadeeswaran,Anthony G. Montag,Amy R. Becker,Hilary A. Kenny,Marcus E. Peter,Vanitha Ramakrishnan,S. Diane Yamada,Ernst Lengyel +13 more
TL;DR: It is shown here that inhibition of E-cadherin in ovarian cancer cells causes up-regulation of alpha(5)-integrin protein expression and transcription, providing an explanation for how E- cadher in loss increases metastasis.
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The initial steps of ovarian cancer cell metastasis are mediated by MMP-2 cleavage of vitronectin and fibronectin
TL;DR: It is shown that MMP-2 expression was upregulated in OvCa cells upon attachment to their microenvironment, and this indicates that M MP-2 expressed by metastatic Ov Ca cells functionally regulates their attachment to peritoneal surfaces.
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Adipocyte-induced CD36 expression drives ovarian cancer progression and metastasis.
Andras Ladanyi,Andras Ladanyi,Abir Mukherjee,Hilary A. Kenny,Alyssa Johnson,Anirban K. Mitra,Sinju Sundaresan,Kristin M Nieman,Gloria Pascual,Salvador Aznar Benitah,Anthony G. Montag,S. Diane Yamada,Nada A. Abumrad,Ernst Lengyel +13 more
TL;DR: Results suggest that omental adipocytes reprogram tumour metabolism through the upregulation of CD36 in OvCa cells and targeting the stromal-tumour metabolic interface via CD36 inhibition may prove to be an effective treatment strategy against OvCa metastasis.
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c-Met Overexpression Is a Prognostic Factor in Ovarian Cancer and an Effective Target for Inhibition of Peritoneal Dissemination and Invasion
Kenjiro Sawada,A. Reza Radjabi,Nariyoshi Shinomiya,Emily O. Kistner,Hilary A. Kenny,Amy R. Becker,Muge Turkyilmaz,Ravi Salgia,S. Diane Yamada,George F. Vande Woude,Maria Tretiakova,Ernst Lengyel +11 more
TL;DR: It is suggested that c-Met overexpression is a prognostic factor in ovarian cancer and that targeting c- met in vivo inhibits peritoneal dissemination and invasion through an alpha(5)beta(1) integrin-dependent mechanism.