H
Hirokazu Matsushita
Researcher at Washington University in St. Louis
Publications - 13
Citations - 3658
Hirokazu Matsushita is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Medicine & Cancer. The author has an hindex of 3, co-authored 3 publications receiving 3104 citations. Previous affiliations of Hirokazu Matsushita include University of Tokyo.
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Journal ArticleDOI
Batf3 Deficiency Reveals a Critical Role for CD8α+ Dendritic Cells in Cytotoxic T Cell Immunity
Kai Hildner,Brian T. Edelson,Whitney E. Purtha,Mark S Diamond,Hirokazu Matsushita,Masako Kohyama,Boris Calderon,Barbara U. Schraml,Emil R. Unanue,Michael S. Diamond,Robert D. Schreiber,Theresa L. Murphy,Kenneth M. Murphy +12 more
TL;DR: An important role is suggested for CD8α+ dendritic cells and cross-presentation in responses to viruses and in tumor rejection in Batf3–/– mice.
Journal ArticleDOI
Cancer exome analysis reveals a T-cell-dependent mechanism of cancer immunoediting
Hirokazu Matsushita,Hirokazu Matsushita,Matthew D. Vesely,Daniel C. Koboldt,Charles G. Rickert,Ravindra Uppaluri,Vincent Magrini,Cora D. Arthur,J. Michael White,Yee Shiuan Chen,Lauren Shea,Jasreet Hundal,Michael C. Wendl,Ryan Demeter,Todd Wylie,James P. Allison,Mark J. Smyth,Mark J. Smyth,Lloyd J. Old,Elaine R. Mardis,Robert D. Schreiber +20 more
TL;DR: It is demonstrated that the strong immunogenicity of an unedited tumour can be ascribed to expression of highly antigenic mutant proteins and shown that outgrowth of tumour cells that lack these strong antigens via a T-cell-dependent immunoselection process represents one mechanism of cancer immunoediting.
Journal ArticleDOI
Type I interferon is selectively required by dendritic cells for immune rejection of tumors
Mark S Diamond,Michelle Kinder,Hirokazu Matsushita,Mona Mashayekhi,Gavin P. Dunn,Jessica M. Archambault,Hsiaoju Lee,Cora D. Arthur,J. Michael White,Ulrich Kalinke,Kenneth M. Murphy,Robert D. Schreiber +11 more
TL;DR: Dendritic cell responsiveness to type I interferon is required for the generation of antitumor T cell responses and tumor rejection.
Journal ArticleDOI
New evaluation of the tumor immune microenvironment of non-small cell lung cancer and its association with prognosis
Shuichi Shinohara,Yusuke Takahashi,Hiroyasu Komuro,Takuya Matsui,Yusuke Sugita,Ayako Demachi-Okamura,Daisuke Muraoka,Hirotomo Takahara,Takeo Nakada,Noriaki Sakakura,Katsuhiro Masago,Manami Miyai,Reina Nishida,Shin Shomura,Yoshiki Shigematsu,Shunzo Hatooka,Hajime Sasano,Fumiaki Watanabe,Katsutoshi Adachi,Kazuya Fujinaga,Shinji Kaneda,Motoshi Takao,T Ohtsuka,Rui Yamaguchi,Hiroaki Kuroda,Hirokazu Matsushita +25 more
TL;DR: The TIME score capturing complex interactions among tumor proliferation, antitumor immunity and immunosuppression could be useful for prognostic predictions or selection of treatment strategies in patients with lung cancer.
Journal ArticleDOI
Association between effector-type regulatory T cells and immune checkpoint expression on CD8+ T cells in malignant ascites from epithelial ovarian cancer
Sho Sato,Hirokazu Matsushita,Daisuke Shintani,Yukari Kobayashi,Nao Fujieda,Akira Yabuno,Tadaaki Nishikawa,Keiichi Fujiwara,Kazuhiro Kakimi,Kosei Hasegawa +9 more
TL;DR: In this article , the association between regulatory T cells (Tregs) and immune checkpoint expression on T cells in the tumor microenvironment of EOC patients was investigated using multi-color flow cytometry.