M
Mariana Boroni
Researcher at State University of Campinas
Publications - 57
Citations - 784
Mariana Boroni is an academic researcher from State University of Campinas. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 11, co-authored 40 publications receiving 448 citations. Previous affiliations of Mariana Boroni include Universidade Federal de Minas Gerais & Ludwig Maximilian University of Munich.
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Journal ArticleDOI
AXL confers intrinsic resistance to osimertinib and advances the emergence of tolerant cells.
Hirokazu Taniguchi,Tadaaki Yamada,Tadaaki Yamada,Rong Wang,Keiko Tanimura,Yuta Adachi,Akihiro Nishiyama,Azusa Tanimoto,Shinji Takeuchi,Luiz H. Araujo,Mariana Boroni,Akihiro Yoshimura,Shinsuke Shiotsu,Isao Matsumoto,Satoshi Watanabe,Toshiaki Kikuchi,Satoru Miura,Hiroshi Tanaka,Takeshi Kitazaki,Hiroyuki Yamaguchi,Hiroshi Mukae,Junji Uchino,Hisanori Uehara,Koichi Takayama,Seiji Yano +24 more
TL;DR: It is shown that AXL, which is activated by osimertinib, can promote the emergence of tolerant lung cancer cell thus conferring resistance to osimERTinib and proposed the combination of Osimert inib with AXL inhibitor as a potential therapeutic approach in such resistant cancers.
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Determinants of RNA metabolism in the Schizosaccharomyces pombe genome
Philipp Eser,Philipp Eser,Leonhard Wachutka,Kerstin C. Maier,Carina Demel,Mariana Boroni,Srignanakshi Iyer,Patrick Cramer,Julien Gagneur +8 more
TL;DR: The approach reveals distinct kinetics of mRNA and ncRNA metabolism, separates antisense regulation by transcription interference from RNA interference, and provides a general tool for studying the regulatory code of genomes.
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Annexin A2 overexpression associates with colorectal cancer invasiveness and TGF-ß induced epithelial mesenchymal transition via Src/ANXA2/STAT3.
Murilo Ramos Rocha,Pedro Barcellos-de-Souza,Annie Cristhine Moraes Sousa-Squiavinato,Priscila Valverde Fernandes,Ivanir Martins de Oliveira,Mariana Boroni,José Andrés Morgado-Díaz +6 more
TL;DR: The association of ANxA2 to distinct CMSs suggests the possible use of ANXA2 as a prognostic marker or directed target therapy and its potential prognostic value.
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The spliced leader trans-splicing mechanism in different organisms: molecular details and possible biological roles.
TL;DR: Evidence that a given SLe will always be related to a given set of transcripts in different species from the same phylum, and therefore, different SLe sequences from the the same species would regulate different sets of transcripts is found.
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Distinct co-expression networks using multi-omic data reveal novel interventional targets in HPV-positive and negative head-and-neck squamous cell cancer.
TL;DR: New insights are provided into complex genetic and epigenetic particularities in the development and progression of HNSCC according to HPV status, and contribute to unveiling specific genes/pathways as novel therapeutic targets in H NSCC.