Hiromi Iwahashi

TL;DR: Results suggest that the decreased plasma adiponectin concentrations in diabetes may be an indicator of macroangiopathy, and weight reduction significantly elevated plasma adip onectin levels in the diabetic subjects as well as the nondiabetic subjects.

TL;DR: Results suggest that Fas-mediated cytotoxicity is required to initiate β cell autoimmunity in NOD mice, suggesting that Fas–Fas ligand system might be critical for autoimmune β cell destruction leading to IDDM.

TL;DR: It is shown that SMN interacts with Bcl-2, another anti-apoptotic protein, and that co-expression of SMN with B cl-2 confers a synergistic preventive effect against Bax-induced or Fas-mediated apoptosis, although SMN itself has only a weak anti-APoptotic activity.

TL;DR: Serum adiponectin concentrations were examined in 46 type 1 diabetic patients and compared them with those of BMI-matched healthy control subjects and found no difference between the levels in male and female patients.

TL;DR: It is found that the interaction between Fas on beta cells and FasL on infiltrating cells might trigger selective apoptotic beta-cell death in inflamed islets, leading to immune-mediated Type I diabetes.