M
Morihiro Matsuda
Researcher at Osaka University
Publications - 128
Citations - 24662
Morihiro Matsuda is an academic researcher from Osaka University. The author has contributed to research in topics: Adipose tissue & Adiponectin. The author has an hindex of 47, co-authored 122 publications receiving 23311 citations. Previous affiliations of Morihiro Matsuda include Japan Society for the Promotion of Science.
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Journal ArticleDOI
Increased oxidative stress in obesity and its impact on metabolic syndrome
Shigetada Furukawa,Takuya Fujita,Michio Shimabukuro,Masanori Iwaki,Yukio Yamada,Yoshimitsu Nakajima,Osamu Nakayama,Makoto Makishima,Morihiro Matsuda,Iichiro Shimomura +9 more
TL;DR: It is suggested that increased oxidative stress in accumulated fat is an early instigator of metabolic syndrome and that the redox state in adipose tissue is a potentially useful therapeutic target for obesity-associated metabolic syndrome.
Journal ArticleDOI
Plasma Concentrations of a Novel, Adipose-Specific Protein, Adiponectin, in Type 2 Diabetic Patients
Kikuko Hotta,Tohru Funahashi,Yukio Arita,Masahiko Takahashi,Morihiro Matsuda,Yoshihisa Okamoto,Hiromi Iwahashi,Hiroshi Kuriyama,Noriyuki Ouchi,Kazuhisa Maeda,Makoto Nishida,Shinji Kihara,Naohiko Sakai,Tadahisa Nakajima,Kyoichi Hasegawa,Masahiro Muraguchi,Yasukazu Ohmoto,Tadashi Nakamura,Shizuya Yamashita,Toshiaki Hanafusa,Yuji Matsuzawa +20 more
TL;DR: Results suggest that the decreased plasma adiponectin concentrations in diabetes may be an indicator of macroangiopathy, and weight reduction significantly elevated plasma adip onectin levels in the diabetic subjects as well as the nondiabetic subjects.
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Diet-induced insulin resistance in mice lacking adiponectin/ACRP30.
Norikazu Maeda,Iichiro Shimomura,Ken Kishida,Hitoshi Nishizawa,Morihiro Matsuda,Hiroyuki Nagaretani,Naoki Furuyama,Hidehiko Kondo,Masahiko Takahashi,Yukio Arita,Ryutaro Komuro,Noriyuki Ouchi,Shinji Kihara,Yoshihiro Tochino,Keiichi Okutomi,Masato Horie,Satoshi Takeda,Toshifumi Aoyama,Tohru Funahashi,Yuji Matsuzawa +19 more
TL;DR: The results indicate that adiponectin/ACRP30 deficiency and high TNF-α levels in KO mice reduced muscle FATP-1 mRNA and IRS-1-mediated insulin signaling, resulting in severe diet-induced insulin resistance.
Journal ArticleDOI
Visfatin: a protein secreted by visceral fat that mimics the effects of insulin.
Atsunori Fukuhara,Morihiro Matsuda,Masako Nishizawa,Katsumori Segawa,Masaki Tanaka,Kae Kishimoto,Yasushi Matsuki,Mirei Murakami,Tomoko Ichisaka,Hiroko Murakami,Eijiro Watanabe,Toshiyuki Takagi,Megumi Akiyoshi,Tsuguteru Ohtsubo,Shinji Kihara,Shizuya Yamashita,Makoto Makishima,Tohru Funahashi,Shinya Yamanaka,Ryuji Hiramatsu,Yuji Matsuzawa,Iichiro Shimomura,Iichiro Shimomura +22 more
TL;DR: A newly identified adipocytokine, visfatin, that is highly enriched in the visceral fat of both humans and mice and whose expression level in plasma increases during the development of obesity is isolated.
Journal ArticleDOI
PPARγ Ligands Increase Expression and Plasma Concentrations of Adiponectin, an Adipose-Derived Protein
Norikazu Maeda,Masahiko Takahashi,Tohru Funahashi,Shinji Kihara,Hitoshi Nishizawa,Ken Kishida,Hiroyuki Nagaretani,Morihiro Matsuda,Ryutaro Komuro,Noriyuki Ouchi,Hiroshi Kuriyama,Kikuko Hotta,Tadashi Nakamura,Iichiro Shimomura,Yuji Matsuzawa +14 more
TL;DR: Thiazolidinediones (TZDs) might prevent atherosclerotic vascular disease in insulin-resistant patients by inducing the production of adiponectin through direct effect on its promoter and antagonizing the effect of TNF-alpha on the adiponECTin promoter.