H
Hiromichi Kawai
Researcher at Shiga University of Medical Science
Publications - 51
Citations - 2342
Hiromichi Kawai is an academic researcher from Shiga University of Medical Science. The author has contributed to research in topics: Diabetes mellitus & Type 2 diabetes. The author has an hindex of 20, co-authored 51 publications receiving 2186 citations. Previous affiliations of Hiromichi Kawai include National Institutes of Health.
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Journal ArticleDOI
Mice Deficient in Sphingosine Kinase 1 Are Rendered Lymphopenic by FTY720
Maria L. Allende,Teiji Sasaki,Hiromichi Kawai,Ana Olivera,Yide Mi,Gerhild van Echten-Deckert,Richard Hajdu,Mark Rosenbach,Carol Ann Keohane,Suzanne M. Mandala,Sarah Spiegel,Richard L. Proia +11 more
TL;DR: The results with these Sphk1 null mice reveal that some key physiologic processes that require S1P receptor signaling, such as vascular development and proper lymphocyte distribution, can occur in the absence of SPHK1.
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Mice lacking complex gangliosides develop Wallerian degeneration and myelination defects
Kazim A. Sheikh,Ji Sun,Yujing Liu,Hiromichi Kawai,Thomas O. Crawford,Richard L. Proia,John W. Griffin,Ronald L. Schnaar +7 more
TL;DR: Results indicate that complex gangliosides function in central myelination and maintaining the integrity of axons and myelin, and support the theory that complex Ganglioside ligands are endogenous ligands for MAG.
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Mice expressing only monosialoganglioside GM3 exhibit lethal audiogenic seizures.
Hiromichi Kawai,Maria L. Allende,Ryuichi Wada,Mari Kono,Kazunori Sango,Chu-Xia Deng,Tsuyoshi Miyakawa,Jacqueline N. Crawley,Norbert Werth,Uwe Bierfreund,Konrad Sandhoff,Richard L. Proia +11 more
TL;DR: It is demonstrated unequivocally that gangliosides play an essential role in the proper functioning of the central nervous system (CNS) and that GD3S−/− mice, even with an absence of b-series ganglioides, appear to undergo normal development and have a normal life span.
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A genetic model of substrate deprivation therapy for a glycosphingolipid storage disorder
Yujing Liu,Ryuichi Wada,Hiromichi Kawai,Kazunori Sango,Chu-Xia Deng,Tadashi Tai,Michael P. McDonald,Kristlyn Araujo,Jacqueline N. Crawley,Uwe Bierfreund,Konrad Sandhoff,Kinuko Suzuki,Richard L. Proia +12 more
TL;DR: The results support the validity of the substrate deprivation therapy and also highlight some limitations.
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Rationale and usefulness of newly devised abbreviated diagnostic criteria and staging for diabetic polyneuropathy.
Hitoshi Yasuda,Mitsuru Sanada,Kanako Kitada,Tomoya Terashima,Hyoh Kim,Yoshio Sakaue,Masashi Fujitani,Hiromichi Kawai,Kengo Maeda,Atsunori Kashiwagi +9 more
TL;DR: In this article, a diagnostic criteria for diabetic polyneuropathy (DP) for daily practice, usefulness of the abbreviated diagnostic criteria proposed by Diabetic Neuropathy Study Group in Japan was examined in 131 diabetic patients in admission and outpatient clinic.