Mice Deficient in Sphingosine Kinase 1 Are Rendered Lymphopenic by FTY720
Maria L. Allende,Teiji Sasaki,Hiromichi Kawai,Ana Olivera,Yide Mi,Gerhild van Echten-Deckert,Richard Hajdu,Mark Rosenbach,Carol Ann Keohane,Suzanne M. Mandala,Sarah Spiegel,Richard L. Proia +11 more
TLDR
The results with these Sphk1 null mice reveal that some key physiologic processes that require S1P receptor signaling, such as vascular development and proper lymphocyte distribution, can occur in the absence of SPHK1.About:
This article is published in Journal of Biological Chemistry.The article was published on 2004-12-10 and is currently open access. It has received 434 citations till now. The article focuses on the topics: Sphingosine kinase 1 & SPHK2.read more
Citations
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Journal ArticleDOI
Promotion of Lymphocyte Egress into Blood and Lymph by Distinct Sources of Sphingosine-1-Phosphate
Rajita Pappu,Susan R. Schwab,Ivo Cornelissen,João Pereira,Jean B. Regard,Ying Xu,Eric Camerer,Yaowu Zheng,Yong Huang,Jason G. Cyster,Shaun R. Coughlin +10 more
TL;DR: Separate sources provide S1P to plasma and lymph to help lymphocytes exit the low-S1P environment of lymphoid organs, and disruption of compartmentalized S 1P signaling is a plausible mechanism by which S1p-receptor-1 agonists function as immunosuppressives.
Book ChapterDOI
An overview of sphingolipid metabolism: from synthesis to breakdown.
TL;DR: This chapter will pay tribute to the complex regulation of simple sphingolipids, a class of lipids defined by their eighteen carbon amino-alcohol backbones that play significant roles in membrane biology and provide many bioactive metabolites that regulate cell function.
Journal ArticleDOI
Sphingosine 1-phosphate and cancer.
Nigel J. Pyne,Susan Pyne +1 more
TL;DR: There is substantial evidence that sphingosine 1-phosphate (S1P) is involved in cancer and the potential for new therapeutics designed to alter S1P signalling and function in cancer is examined.
Journal ArticleDOI
Essential role for sphingosine kinases in neural and vascular development.
Kiyomi Mizugishi,Tadashi Yamashita,Ana Olivera,Georgina F. Miller,Sarah Spiegel,Richard L. Proia +5 more
TL;DR: It is shown that S1P signaling is critical for neural and vascular development and joins a growing list of signaling molecules, such as vascular endothelial growth factor, which regulate the functionally intertwined pathways of angiogenesis and neurogenesis.
Journal ArticleDOI
Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2
Sergio E. Alvarez,Kuzhuvelil B. Harikumar,Nitai C. Hait,Jeremy C. Allegood,Graham M. Strub,Eugene Y. Kim,Michael Maceyka,Hualiang Jiang,Cheng Luo,Tomasz Kordula,Sheldon Milstien,Sarah Spiegel +11 more
TL;DR: The data show that TRAF2 is a novel intracellular target of S1p, and that S1P is the missing cofactor for TRAF 2 E3 ubiquitin ligase activity, indicating a new paradigm for the regulation of lysine-63-linked polyubiquitination.
References
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Journal ArticleDOI
Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1
Mehrdad Matloubian,Charles G. Lo,Guy Cinamon,Matthew J. Lesneski,Ying Xu,Volker Brinkmann,Maria L. Allende,Richard L. Proia,Jason G. Cyster +8 more
TL;DR: It is established that S1P1 is essential for lymphocyte recirculation and that it regulates egress from both thymus and peripheral lymphoid organs.
Journal ArticleDOI
Sphingosine-1-phosphate: an enigmatic signalling lipid
Sarah Spiegel,Sheldon Milstien +1 more
TL;DR: The evolutionarily conserved actions of the sphingolipid metabolite, sphingosine-1-phosphate (S1P), in yeast, plants and mammals have shown that it has important functions.
Journal ArticleDOI
Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists.
Suzanne M. Mandala,Richard Hajdu,James D. Bergstrom,Elizabeth J. Quackenbush,Jenny Xie,James A. Milligan,Rosemary A. Thornton,Gan-Ju Shei,Deborah Card,CarolAnn Keohane,Mark Rosenbach,Jeffrey J. Hale,Christopher L. Lynch,Kathleen M. Rupprecht,William H. Parsons,Hugh Rosen +15 more
TL;DR: It is shown that lymphocyte trafficking is altered by the lysophospholipid sphingosine-1-phosphate (S1P) and by a phosphoryl metabolites of the immunosuppressive agent FTY720.
Journal ArticleDOI
The immune modulator FTY720 targets sphingosine 1-phosphate receptors.
Volker Brinkmann,Michael Davis,Christopher E. Heise,R. Albert,Sylvain Cottens,Robert Paul Hof,Christian Bruns,Eva Prieschl,Thomas Baumruker,Peter Hiestand,Carolyn An Foster,Markus Zollinger,Kevin R. Lynch +12 more
TL;DR: The results suggest that FTY720, after phosphorylation, acts through sphingosine 1-phosphate signaling pathways to modulate chemotactic responses and lymphocyte trafficking.
Journal ArticleDOI
Edg-1, the G protein–coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation
Yujing Liu,Ryuichi Wada,Tadashi Yamashita,Yide Mi,Chu-Xia Deng,John P. Hobson,Hans M. Rosenfeldt,Victor E. Nava,Sung Suk Chae,Menq Jer Lee,Catherine H. Liu,Timothy Hla,Sarah Spiegel,Richard L. Proia +13 more
TL;DR: The data reveal Edg-1 to be the first G protein-coupled receptor required for blood vessel formation and show that sphingolipid signaling is essential during mammalian development.