Gerhild van Echten-Deckert

TL;DR: The results with these Sphk1 null mice reveal that some key physiologic processes that require S1P receptor signaling, such as vascular development and proper lymphocyte distribution, can occur in the absence of SPHK1.

TL;DR: The studies have conclusively established the pathway of ceramide synthesis via desaturation of dihydroceramide and uncovered several properties of this reaction that warrant further consideration for their relevance to both sphingolipid metabolism and signaling.

TL;DR: It is reported that Profftella is a defensive symbiont presumably of an obligate nature with an extremely streamlined genome, suggesting their ancient and mutually indispensible association with the host.

TL;DR: The membrane lipid composition could play important roles in trafficking and metabolism of Alzheimer's disease related proteins and sphingolipids emerged to important modulators of biological processes including cell growth, differentiation, and senescence.

TL;DR: In lymphocyte plasma membranes, Lck and Fyn kinases exhibit optimal activity when juxtaposed to the GPI- and sphingolipid-enriched core microdomains but encounter inhibitory conditions in surrounding membrane areas that are rich in glycerophospholipids and contain additional transmembrane proteins.