H
Hiroyuki Nagaretani
Researcher at Osaka University
Publications - 22
Citations - 9066
Hiroyuki Nagaretani is an academic researcher from Osaka University. The author has contributed to research in topics: Adiponectin & Adipose tissue. The author has an hindex of 20, co-authored 22 publications receiving 8758 citations.
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Journal ArticleDOI
Diet-induced insulin resistance in mice lacking adiponectin/ACRP30.
Norikazu Maeda,Iichiro Shimomura,Ken Kishida,Hitoshi Nishizawa,Morihiro Matsuda,Hiroyuki Nagaretani,Naoki Furuyama,Hidehiko Kondo,Masahiko Takahashi,Yukio Arita,Ryutaro Komuro,Noriyuki Ouchi,Shinji Kihara,Yoshihiro Tochino,Keiichi Okutomi,Masato Horie,Satoshi Takeda,Toshifumi Aoyama,Tohru Funahashi,Yuji Matsuzawa +19 more
TL;DR: The results indicate that adiponectin/ACRP30 deficiency and high TNF-α levels in KO mice reduced muscle FATP-1 mRNA and IRS-1-mediated insulin signaling, resulting in severe diet-induced insulin resistance.
Journal ArticleDOI
PPARγ Ligands Increase Expression and Plasma Concentrations of Adiponectin, an Adipose-Derived Protein
Norikazu Maeda,Masahiko Takahashi,Tohru Funahashi,Shinji Kihara,Hitoshi Nishizawa,Ken Kishida,Hiroyuki Nagaretani,Morihiro Matsuda,Ryutaro Komuro,Noriyuki Ouchi,Hiroshi Kuriyama,Kikuko Hotta,Tadashi Nakamura,Iichiro Shimomura,Yuji Matsuzawa +14 more
TL;DR: Thiazolidinediones (TZDs) might prevent atherosclerotic vascular disease in insulin-resistant patients by inducing the production of adiponectin through direct effect on its promoter and antagonizing the effect of TNF-alpha on the adiponECTin promoter.
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Reciprocal Association of C-Reactive Protein With Adiponectin in Blood Stream and Adipose Tissue
Noriyuki Ouchi,Shinji Kihara,Tohru Funahashi,Tadashi Nakamura,Makoto Nishida,Masahiro Kumada,Yoshihisa Okamoto,Koji Ohashi,Hiroyuki Nagaretani,Ken Kishida,Hitoshi Nishizawa,Norikazu Maeda,Hideki Kobayashi,Hisatoyo Hiraoka,Yuji Matsuzawa +14 more
TL;DR: The reciprocal association of adiponectin and CRP levels in both human plasma and adipose tissue might participate in the development of atherosclerosis.
Journal ArticleDOI
Androgens Decrease Plasma Adiponectin, an Insulin-Sensitizing Adipocyte-Derived Protein
Hitoshi Nishizawa,Iichiro Shimomura,Ken Kishida,Norikazu Maeda,Hiroshi Kuriyama,Hiroyuki Nagaretani,Morihiro Matsuda,Hidehiko Kondo,Naoki Furuyama,Shinji Kihara,Tadashi Nakamura,Yoshihiro Tochino,Tohru Funahashi,Yuji Matsuzawa +13 more
TL;DR: The results indicate that androgens decrease plasma adiponectin and that androgen-induced hypoadiponectinemia may be related to the high risks of insulin resistance and atherosclerosis in men.
Journal ArticleDOI
Role of Adiponectin in Preventing Vascular Stenosis THE MISSING LINK OF ADIPO-VASCULAR AXIS
Morihiro Matsuda,Iichiro Shimomura,Masataka Sata,Yukio Arita,Makoto Nishida,Norikazu Maeda,Masahiro Kumada,Yoshihisa Okamoto,Hiroyuki Nagaretani,Hitoshi Nishizawa,Ken Kishida,Ryutaro Komuro,Noriyuki Ouchi,Shinji Kihara,Ryozo Nagai,Tohru Funahashi,Yuji Matsuzawa +16 more
TL;DR: An adipo-vascular axis, a direct link between fat and artery, is suggested and a therapeutic strategy to increase plasma adiponectin should be useful in preventing vascular restenosis after angioplasty.