Androgens Decrease Plasma Adiponectin, an Insulin-Sensitizing Adipocyte-Derived Protein
Hitoshi Nishizawa,Iichiro Shimomura,Ken Kishida,Norikazu Maeda,Hiroshi Kuriyama,Hiroyuki Nagaretani,Morihiro Matsuda,Hidehiko Kondo,Naoki Furuyama,Shinji Kihara,Tadashi Nakamura,Yoshihiro Tochino,Tohru Funahashi,Yuji Matsuzawa +13 more
TLDR
The results indicate that androgens decrease plasma adiponectin and that androgen-induced hypoadiponectinemia may be related to the high risks of insulin resistance and atherosclerosis in men.Abstract:
Adiponectin, an adipose-specific secretory protein, exhibits antidiabetic and antiatherogenic properties. In the present study, we examined the effects of sex hormones on the regulation of adiponectin production. Plasma adiponectin concentrations were significantly lower in 442 men (age, 52.6 ± 11.9 years [mean ± SD]) than in 137 women (53.2 ± 12.0 years) but not different between pre- and postmenopausal women. In mice, ovariectomy did not alter plasma adiponectin levels. In contrast, high levels of plasma adiponectin were found in castrated mice. Testosterone treatment reduced plasma adiponectin concentration in both sham-operated and castrated mice. In 3T3-L1 adipocytes, testosterone reduced adiponectin secretion into the culture media, using pulse-chase study. Castration-induced increase in plasma adiponectin was associated with a significant improvement of insulin sensitivity. Our results indicate that androgens decrease plasma adiponectin and that androgen-induced hypoadiponectinemia may be related to the high risks of insulin resistance and atherosclerosis in men.read more
Citations
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Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome
TL;DR: The pathophysiology of adiponectin and adiponECTin receptors in insulin resistance, diabetes, and the metabolic syndrome is described and potential versatile therapeutic targets to combat obesity-linked diseases characterized by insulin resistance are described.
Journal ArticleDOI
Adiponectin and Adiponectin Receptors
TL;DR: It is shown that AdipoR1 and AdIPoR2 serve as receptors for globular and full-length adiponectin and mediate increased AMP-activated protein kinase, peroxisome proliferator-activated receptor-alpha ligand activities, and glucose uptake and fatty-acid oxidation by adiponECTin.
Journal ArticleDOI
Relationship of adiponectin to body fat distribution, insulin sensitivity and plasma lipoproteins: evidence for independent roles of age and sex.
Miriam Cnop,Peter J. Havel,Kristina M. Utzschneider,Daniel B. Carr,Madhur K. Sinha,Edward J. Boyko,Barbara M. Retzlaff,Robert H. Knopp,John D. Brunzell,Steven E. Kahn +9 more
TL;DR: It is suggested that adiponectin concentrations are determined by intra-abdominal fat mass, with additional independent effects of age and sex, and could link intra- abdominalFat with insulin resistance and an atherogenic lipoprotein profile.
Journal ArticleDOI
Association of Hypoadiponectinemia With Coronary Artery Disease in Men
Masahiro Kumada,Shinji Kihara,Satoru Sumitsuji,Toshiharu Kawamoto,Satoru Matsumoto,Noriyuki Ouchi,Yukio Arita,Yoshihisa Okamoto,Iichiro Shimomura,Hisatoyo Hiraoka,Tadashi Nakamura,Tohru Funahashi,Yuji Matsuzawa +12 more
TL;DR: Male patients with hypoadiponectinemia had a significant 2-fold increase in CAD prevalence, independent of well-known CAD risk factors.
Journal ArticleDOI
The Emergence of the Metabolic Syndrome with Menopause
TL;DR: The features of the metabolic syndrome that emerge with estrogen deficiency are reviewed to aid in the recognition and treatment of women at risk for future CVD, leading to appropriate interventions.
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