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Yoshihiro Tochino
Researcher at Osaka University
Publications - 61
Citations - 7016
Yoshihiro Tochino is an academic researcher from Osaka University. The author has contributed to research in topics: Insulin & Adipose tissue. The author has an hindex of 29, co-authored 57 publications receiving 6644 citations. Previous affiliations of Yoshihiro Tochino include Setsunan University & Kurume University.
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Journal ArticleDOI
Diet-induced insulin resistance in mice lacking adiponectin/ACRP30.
Norikazu Maeda,Iichiro Shimomura,Ken Kishida,Hitoshi Nishizawa,Morihiro Matsuda,Hiroyuki Nagaretani,Naoki Furuyama,Hidehiko Kondo,Masahiko Takahashi,Yukio Arita,Ryutaro Komuro,Noriyuki Ouchi,Shinji Kihara,Yoshihiro Tochino,Keiichi Okutomi,Masato Horie,Satoshi Takeda,Toshifumi Aoyama,Tohru Funahashi,Yuji Matsuzawa +19 more
TL;DR: The results indicate that adiponectin/ACRP30 deficiency and high TNF-α levels in KO mice reduced muscle FATP-1 mRNA and IRS-1-mediated insulin signaling, resulting in severe diet-induced insulin resistance.
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Adipose Tissue Hypoxia in Obesity and Its Impact on Adipocytokine Dysregulation
Naomi Hosogai,Atsunori Fukuhara,Kazuya Oshima,Yugo Miyata,Sachiyo Tanaka,Katsumori Segawa,Shigetada Furukawa,Yoshihiro Tochino,Ryutaro Komuro,Morihiro Matsuda,Iichiro Shimomura +10 more
TL;DR: It is shown that adipose tissue of obese mice is hypoxic and that local adipose tissues hypoxia dysregulates the production of adipocytokines, and the results suggest that hypoperfusion and Hypoxia in adipose organs underlie the dysregulated production of fat-derived secretory factors and metabolic syndrome in obesity.
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Androgens Decrease Plasma Adiponectin, an Insulin-Sensitizing Adipocyte-Derived Protein
Hitoshi Nishizawa,Iichiro Shimomura,Ken Kishida,Norikazu Maeda,Hiroshi Kuriyama,Hiroyuki Nagaretani,Morihiro Matsuda,Hidehiko Kondo,Naoki Furuyama,Shinji Kihara,Tadashi Nakamura,Yoshihiro Tochino,Tohru Funahashi,Yuji Matsuzawa +13 more
TL;DR: The results indicate that androgens decrease plasma adiponectin and that androgen-induced hypoadiponectinemia may be related to the high risks of insulin resistance and atherosclerosis in men.
Journal ArticleDOI
Quantitative determination of cytochrome P-450 in rat liver homogenate
TL;DR: The content of cytochrome P -450 in normal rat liver was estimated to be 50 nmol/g wet weight of liver, and increased significantly after pretreatment of the animals with either phenobarbital or 3-methylcholanthrene.
Journal ArticleDOI
Uric acid secretion from adipose tissue and its increase in obesity
Yu Tsushima,Hitoshi Nishizawa,Yoshihiro Tochino,Hideaki Nakatsuji,Ryohei Sekimoto,Hirofumi Nagao,Takashi Shirakura,Kenta Kato,Keiichiro Imaizumi,Hiroyuki Takahashi,Mizuho Tamura,Norikazu Maeda,Tohru Funahashi,Iichiro Shimomura +13 more
TL;DR: It is reported, using mouse models, that adipose tissue could produce and secrete uric acid through xanthine oxidoreductase (XOR) and that the production was enhanced in obesity, and the results suggest that purine catabolism in adipOSE tissue could be enhanced in Obesity.