H
Hisatomo Kowa
Researcher at RMIT University
Publications - 56
Citations - 1419
Hisatomo Kowa is an academic researcher from RMIT University. The author has contributed to research in topics: Medicine & Disease. The author has an hindex of 15, co-authored 47 publications receiving 1157 citations. Previous affiliations of Hisatomo Kowa include Harvard University & Kitasato University.
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Noncoding CGG repeat expansions in neuronal intranuclear inclusion disease, oculopharyngodistal myopathy and an overlapping disease.
Hiroyuki Ishiura,Shota Shibata,Jun Yoshimura,Yuta Suzuki,Wei Qu,Koichiro Doi,Koichiro Doi,M. Asem Almansour,Junko Kanda Kikuchi,Makiko Taira,Makiko Taira,Jun Mitsui,Yuji Takahashi,Yaeko Ichikawa,Yaeko Ichikawa,Tatsuo Mano,Atsushi Iwata,Yasuo Harigaya,Miho Matsukawa,Takashi Matsukawa,Masaki Tanaka,Masaki Tanaka,Yuichiro Shirota,Ryo Ohtomo,Hisatomo Kowa,Hisatomo Kowa,Hidetoshi Date,Aki Mitsue,Hiroyuki Hatsuta,Satoru Morimoto,Shigeo Murayama,Yasushi Shiio,Yuko Saito,Akihiko Mitsutake,Mizuho Kawai,Takuya Sasaki,Yusuke Sugiyama,Masashi Hamada,Gaku Ohtomo,Yasuo Terao,Yasuo Terao,Yoshihiko Nakazato,Akitoshi Takeda,Yoshio Sakiyama,Yumi Umeda-Kameyama,Jun Shinmi,Katsuhisa Ogata,Yutaka Kohno,Shen-Yang Lim,Ai Huey Tan,Jun Shimizu,Jun Goto,Jun Goto,Ichizo Nishino,Tatsushi Toda,Shinichi Morishita,Shoji Tsuji,Shoji Tsuji +57 more
TL;DR: Whole-genome sequencing identifies noncoding CGG repeat expansions in neuronal intranuclear inclusion disease, oculopharyngodistal myopathy and Oculopharyngealmyopathy with leukoencephalopathy, three disorders with overlapping clinical features and neuroimaging findings.
Journal ArticleDOI
CLAC: a novel Alzheimer amyloid plaque component derived from a transmembrane precursor, CLAC-P/collagen type XXV
Tadafumi Hashimoto,Tomoko Wakabayashi,Atsushi Watanabe,Hisatomo Kowa,Ritsuko Hosoda,Atsushi Nakamura,Ichiro Kanazawa,Takao Arai,Koji Takio,David M. A. Mann,Takeshi Iwatsubo +10 more
TL;DR: Both secreted and membrane‐tethered forms of CLAC‐P/collagen type XXV specifically bound to fibrillized Aβ, implicating these proteins in β‐amyloidogenesis and neuronal degeneration in AD.
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Familial Parkinson Mutant α-Synuclein Causes Dopamine Neuron Dysfunction in Transgenic Caenorhabditis elegans
Tomoki Kuwahara,Akihiko Koyama,Keiko Gengyo-Ando,Mayumi Masuda,Hisatomo Kowa,Makoto Tsunoda,Shohei Mitani,Takeshi Iwatsubo +7 more
TL;DR: The present TG worms exhibit dopamine neuron-specific dysfunction caused by accumulation of α-synuclein, which would be relevant to the genetic and compound screenings aiming at the elucidation of pathological cascade and therapeutic strategies for Parkinson disease.
Journal ArticleDOI
Expression of APP pathway mRNAs and proteins in Alzheimer’s disease
Toshifumi Matsui,Martin Ingelsson,Hiroaki Fukumoto,Karunya Ramasamy,Hisatomo Kowa,Matthew P. Frosch,Michael C. Irizarry,Bradley T. Hyman +7 more
TL;DR: Altered transcription of APP in AD is proportionately associated with Abeta peptide, may occur in the context of gliosis, and may contribute to Abeta deposition in sporadic AD.