S
Satoru Morimoto
Researcher at Keio University
Publications - 60
Citations - 744
Satoru Morimoto is an academic researcher from Keio University. The author has contributed to research in topics: Medicine & Amyotrophic lateral sclerosis. The author has an hindex of 11, co-authored 42 publications receiving 386 citations. Previous affiliations of Satoru Morimoto include Mie University.
Papers
More filters
Journal ArticleDOI
Noncoding CGG repeat expansions in neuronal intranuclear inclusion disease, oculopharyngodistal myopathy and an overlapping disease.
Hiroyuki Ishiura,Shota Shibata,Jun Yoshimura,Yuta Suzuki,Wei Qu,Koichiro Doi,Koichiro Doi,M. Asem Almansour,Junko Kanda Kikuchi,Makiko Taira,Makiko Taira,Jun Mitsui,Yuji Takahashi,Yaeko Ichikawa,Yaeko Ichikawa,Tatsuo Mano,Atsushi Iwata,Yasuo Harigaya,Miho Matsukawa,Takashi Matsukawa,Masaki Tanaka,Masaki Tanaka,Yuichiro Shirota,Ryo Ohtomo,Hisatomo Kowa,Hisatomo Kowa,Hidetoshi Date,Aki Mitsue,Hiroyuki Hatsuta,Satoru Morimoto,Shigeo Murayama,Yasushi Shiio,Yuko Saito,Akihiko Mitsutake,Mizuho Kawai,Takuya Sasaki,Yusuke Sugiyama,Masashi Hamada,Gaku Ohtomo,Yasuo Terao,Yasuo Terao,Yoshihiko Nakazato,Akitoshi Takeda,Yoshio Sakiyama,Yumi Umeda-Kameyama,Jun Shinmi,Katsuhisa Ogata,Yutaka Kohno,Shen-Yang Lim,Ai Huey Tan,Jun Shimizu,Jun Goto,Jun Goto,Ichizo Nishino,Tatsushi Toda,Shinichi Morishita,Shoji Tsuji,Shoji Tsuji +57 more
TL;DR: Whole-genome sequencing identifies noncoding CGG repeat expansions in neuronal intranuclear inclusion disease, oculopharyngodistal myopathy and Oculopharyngealmyopathy with leukoencephalopathy, three disorders with overlapping clinical features and neuroimaging findings.
Journal ArticleDOI
Ropinirole, a New ALS Drug Candidate Developed Using iPSCs.
Hideyuki Okano,Daisuke Yasuda,Koki Fujimori,Satoru Morimoto,Shinichi Takahashi,Shinichi Takahashi +5 more
TL;DR: The preclinical data, clinical research design, and rationale for ROPI as an anti-ALS drug candidate compared with those of the other two drugs are reviewed and the use of iPSCs for understanding and monitoring treatment response is discussed.
Journal ArticleDOI
Aberrant axon branching via Fos-B dysregulation in FUS-ALS motor neurons
Tetsuya Akiyama,Naoki Suzuki,Mitsuru Ishikawa,Koki Fujimori,Takefumi Sone,Jiro Kawada,Ryo Funayama,Fumiyoshi Fujishima,Shio Mitsuzawa,Kensuke Ikeda,Hiroya Ono,Tomomi Shijo,Shion Osana,Matsuyuki Shirota,Tadashi Nakagawa,Yasuo Kitajima,Ayumi Nishiyama,Rumiko Izumi,Satoru Morimoto,Yohei Okada,Takayuki Kamei,Mayumi Nishida,Masahiro Nogami,Shohei Kaneda,Yoshiho Ikeuchi,Hiroaki Mitsuhashi,Keiko Nakayama,Teruo Fujii,Hitoshi Warita,Hideyuki Okano,Masashi Aoki +30 more
TL;DR: Analyzing the axonal fraction of hiPSC-derived MNs using microfluidic devices revealed that Fos-B is a key regulator of FUS-mutant axon branching, which is a novel phenotype and confirmed with other ALS causative mutation than FUS.
Journal ArticleDOI
iPSC-based disease modeling and drug discovery in cardinal neurodegenerative disorders.
Hideyuki Okano,Satoru Morimoto +1 more
TL;DR: In this paper , a review outlines advances in iPSC modeling and therapeutic development for cardinal neurodegenerative diseases, such as amyotrophic lateral sclerosis, Parkinson's disease, and Alzheimer's disease.
Journal ArticleDOI
Homovanillic acid and 5-hydroxyindole acetic acid as biomarkers for dementia with Lewy bodies and coincident Alzheimer's disease: An autopsy-confirmed study.
Satoru Morimoto,Masaki Takao,Hiroyuki Hatsuta,Yasushi Nishina,Tadashi Komiya,Renpei Sengoku,Yuta Nakano,Akiko Uchino,Hiroyuki Sumikura,Yuko Saito,Kazutomi Kanemaru,Shigeo Murayama +11 more
TL;DR: CSF levels of HVA and 5-HIAA were consistently decreased in pathologically advanced Lewy body disorder (LBD) compared with pathologically incipient LBD (Braak LB stages <2), and results suggest that if an individual has LB pathology in the central nervous system, CSF levels may decrease after the onset of clinical symptoms.