H
Hidetoshi Date
Researcher at University of Tokyo
Publications - 14
Citations - 1753
Hidetoshi Date is an academic researcher from University of Tokyo. The author has contributed to research in topics: Trinucleotide repeat expansion & Aprataxin. The author has an hindex of 13, co-authored 14 publications receiving 1430 citations.
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Journal ArticleDOI
CpG Demethylation Enhances Alpha-Synuclein Expression and Affects the Pathogenesis of Parkinson's Disease
Lumine Matsumoto,Hiroshi Takuma,Akira Tamaoka,Hiroshi Kurisaki,Hidetoshi Date,Shoji Tsuji,Atsushi Iwata,Atsushi Iwata +7 more
TL;DR: The findings suggest that a novel epigenetic regulatory mechanism controlling SNCA expression influences PD pathogenesis, and this CpG region may function as an intronic regulatory element for S NCA gene.
Journal ArticleDOI
Mutations in COQ2 in familial and sporadic multiple-system atrophy the multiple-system atrophy research collaboration
Jun Mitsui,Takashi Matsukawa,Hiroyuki Ishiura,Yoko Fukuda,Yoko Fukuda,Yaeko Ichikawa,Hidetoshi Date,Budrul Ahsan,Yasuo Nakahara,Yoshio Momose,Yuji Takahashi,Atsushi Iwata,Jun Goto,Yorihiro Yamamoto,Makiko Komata,Katsuhiko Shirahige,Kenju Hara,Akiyoshi Kakita,Mitsunori Yamada,Hitoshi Takahashi,Osamu Onodera,Masatoyo Nishizawa,Hiroshi Takashima,Ryozo Kuwano,Hirohisa Watanabe,Mizuki Ito,Gen Sobue,Hiroyuki Soma,Ichiro Yabe,Hidenao Sasaki,Masashi Aoki,Kinya Ishikawa,Hidehiro Mizusawa,Kazuaki Kanai,Takamichi Hattori,Satoshi Kuwabara,Kimihito Arai,Shigeru Koyano,Yoshiyuki Kuroiwa,Kazuko Hasegawa,Tatsuhiko Yuasa,Kenichi Yasui,Kenji Nakashima,Hijiri Ito,Yuishin Izumi,Ryuji Kaji,Takeo Kato,Susumu Kusunoki,Yasushi Osaki,Masahiro Horiuchi,Tomoyoshi Kondo,Shigeo Murayama,Nobutaka Hattori,Mitsutoshi Yamamoto,Miho Murata,Wataru Satake,Tatsushi Toda,Alexandra Durr,Alexis Brice,Alessandro Filla,Thomas Klockgether,Ullrich Wallner,Garth A. Nicholson,Sid Gilman,Clifford W. Shults,Caroline M. Tanner,Walter A. Kukull,Virginia M.-Y. Lee,Eliezer Masliah,Phillip A. Low,Paola Sandroni,John Q. Trojanowski,Laurie J. Ozelius,Tatiana Foroud,Shoji Tsuji +74 more
TL;DR: Functionally impaired variants of COQ2 were associated with an increased risk of multiple-system atrophy in multiplex families and patients with sporadic disease, providing evidence of a role of impaired COQ1 activities in the pathogenesis of this disease.
Journal ArticleDOI
Noncoding CGG repeat expansions in neuronal intranuclear inclusion disease, oculopharyngodistal myopathy and an overlapping disease.
Hiroyuki Ishiura,Shota Shibata,Jun Yoshimura,Yuta Suzuki,Wei Qu,Koichiro Doi,Koichiro Doi,M. Asem Almansour,Junko Kanda Kikuchi,Makiko Taira,Makiko Taira,Jun Mitsui,Yuji Takahashi,Yaeko Ichikawa,Yaeko Ichikawa,Tatsuo Mano,Atsushi Iwata,Yasuo Harigaya,Miho Matsukawa,Takashi Matsukawa,Masaki Tanaka,Masaki Tanaka,Yuichiro Shirota,Ryo Ohtomo,Hisatomo Kowa,Hisatomo Kowa,Hidetoshi Date,Aki Mitsue,Hiroyuki Hatsuta,Satoru Morimoto,Shigeo Murayama,Yasushi Shiio,Yuko Saito,Akihiko Mitsutake,Mizuho Kawai,Takuya Sasaki,Yusuke Sugiyama,Masashi Hamada,Gaku Ohtomo,Yasuo Terao,Yasuo Terao,Yoshihiko Nakazato,Akitoshi Takeda,Yoshio Sakiyama,Yumi Umeda-Kameyama,Jun Shinmi,Katsuhisa Ogata,Yutaka Kohno,Shen-Yang Lim,Ai Huey Tan,Jun Shimizu,Jun Goto,Jun Goto,Ichizo Nishino,Tatsushi Toda,Shinichi Morishita,Shoji Tsuji,Shoji Tsuji +57 more
TL;DR: Whole-genome sequencing identifies noncoding CGG repeat expansions in neuronal intranuclear inclusion disease, oculopharyngodistal myopathy and Oculopharyngealmyopathy with leukoencephalopathy, three disorders with overlapping clinical features and neuroimaging findings.
Journal ArticleDOI
Expansions of intronic TTTCA and TTTTA repeats in benign adult familial myoclonic epilepsy.
Hiroyuki Ishiura,Koichiro Doi,Jun Mitsui,Jun Yoshimura,Miho Matsukawa,Asao Fujiyama,Yasuko Toyoshima,Akiyoshi Kakita,Hitoshi Takahashi,Yutaka Suzuki,Sumio Sugano,Wei Qu,Kazuki Ichikawa,Hideaki Yurino,Koichiro Higasa,Shota Shibata,Aki Mitsue,Masaki Tanaka,Yaeko Ichikawa,Yuji Takahashi,Hidetoshi Date,Takashi Matsukawa,Junko Kanda,Fumiko Kusunoki Nakamoto,Mana Higashihara,Koji Abe,Ryoko Koike,Mutsuo Sasagawa,Yasuko Kuroha,Naoya Hasegawa,Norio Kanesawa,Takayuki Kondo,Takefumi Hitomi,Masayoshi Tada,Hiroki Takano,Yutaka Saito,Kazuhiro Sanpei,Osamu Onodera,Masatoyo Nishizawa,Masayuki Nakamura,Takeshi Yasuda,Yoshio Sakiyama,Mieko Otsuka,Akira Ueki,K. Kaida,Jun Shimizu,Ritsuko Hanajima,Toshihiro Hayashi,Yasuo Terao,Satomi Inomata-Terada,Masashi Hamada,Yuichiro Shirota,Akatsuki Kubota,Yoshikazu Ugawa,Kishin Koh,Yoshihisa Takiyama,Natsumi Ohsawa-Yoshida,Shoichi Ishiura,Shoichi Ishiura,Ryo Yamasaki,Akira Tamaoka,Hiroshi Akiyama,Taisuke Otsuki,Akira Sano,Akio Ikeda,Jun Goto,Shinichi Morishita,Shoji Tsuji,Shoji Tsuji +68 more
TL;DR: It is shown that abnormal expansions of TTTCA and TTTTA repeats in intron 4 of SAMD12 cause benign adult familial myoclonic epilepsy (BAFME), and RNA toxicity as the mechanism underlying disease pathogenesis is identified.
Journal ArticleDOI
IFNβ-1b may severely exacerbate Japanese optic-spinal MS in neuromyelitis optica spectrum
Jun Shimizu,Yuki Hatanaka,Masato Hasegawa,Atsushi Iwata,I. Sugimoto,Hidetoshi Date,Jun Goto,Teruo Shimizu,M. Takatsu,Yasuhisa Sakurai,Hirofumi Nakase,Yoshikazu Uesaka,Hideji Hashida,K. Hashimoto,T. Komiya,Shoji Tsuji +15 more
TL;DR: It is suggested that IFNβ-1b may trigger severe exacerbation in patients with the NMO spectrum and cases in N MO spectrum should be carefully excluded in INFβ- 1b therapy.