Laurent Perez

TL;DR: It is ascertained that a human survivor of the 1995 Kikwit Ebola virus disease outbreak maintained circulating antibodies against the Ebola virus surface glycoprotein for more than a decade after infection, suggesting that a simplified therapeutic strategy for human Ebola infection may be possible.

TL;DR: The structure-based design of a self-assembling protein nanoparticle presenting a prefusion-stabilized variant of the F glycoprotein trimer (DS-Cav1) in a repetitive array on the nanoparticle exterior is described and computationally designed two-component nanoparticles are established as a robust and customizable platform for structure- based vaccine design.

TL;DR: A human monoclonal antibody (MPE8) that potently cross-neutralizes HRSV and HMPV as well as two animal paramyxoviruses and shows potent prophylactic and therapeutic efficacy and identifies the pre-fusion F protein as a candidate H RSV vaccine.

TL;DR: This study isolated IgM and IgG monoclonal antibodies from Tanzanian volunteers who were immunized with repeated injection of Sanaria PfSPZ Vaccine and who were found to be protected from controlled human malaria infection with infectious homologous PfSPzs.

TL;DR: These findings help explain the broad tropism of human cytomegalovirus and indicate that PDGFRα and the viral gO subunit could be targeted by novel anti-viral therapies.