H
Hong Duck Kim
Researcher at New York Medical College
Publications - 46
Citations - 1661
Hong Duck Kim is an academic researcher from New York Medical College. The author has contributed to research in topics: Adipogenesis & Adipocyte. The author has an hindex of 15, co-authored 40 publications receiving 1483 citations. Previous affiliations of Hong Duck Kim include University of Illinois at Chicago & University of Alabama at Birmingham.
Papers
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Journal ArticleDOI
Role of toll-like receptor signalling in Aβ uptake and clearance
TL;DR: In this paper, the role of TLR4 in the amyloidogenesis in vivo, determined the amounts of cerebral Abeta in Alzheimer's disease mouse models with different genotypes of TLRs using three distinct methods.
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Toll-like receptor 4-dependent upregulation of cytokines in a transgenic mouse model of Alzheimer's disease
TL;DR: The first demonstration of TLR4-dependent upregulation of cytokines in an AD mouse model is demonstrated and suggests that TLR 4 signaling is involved in AD progression and thatTLR4 signaling can be a new therapeutic target for AD.
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TLR4 mutation reduces microglial activation, increases Aβ deposits and exacerbates cognitive deficits in a mouse model of Alzheimer's disease
Min Song,Jing-Ji Jin,Jeong Eun Lim,Jinghong Kou,Abhinandan Pattanayak,Jamaal A. Rehman,Hong Duck Kim,Kazuki Tahara,Robert Lalonde,Robert Lalonde,Ken Ichiro Fukuchi +10 more
TL;DR: The results indicate that TLR4 is not involved in the initiation of Aβ deposition and that, as Aβ deposits start, microglia are activated viaTLR4 signaling to reduce A β deposits and preserve cognitive functions from Aβ-mediated neurotoxicity.
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Exploratory activity and spatial learning in 12-month-old APP695SWE/co+PS1/ΔE9 mice with amyloid plaques
Robert Lalonde,Hong Duck Kim,Hong Duck Kim,J.A. Maxwell,J.A. Maxwell,Ken-ichiro Fukuchi,Ken-ichiro Fukuchi +6 more
TL;DR: In the Morris water maze, APP(695)SWE/co+PS1/DeltaE9 mice were impaired during acquisition of the hidden platform sub-task and the probe trial but not in the visible platform test, indicating a selective spatial deficit and disinhibitory tendencies in a mouse model with amyloid pathology.
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Anti-Aβ single chain antibody delivery via adeno-associated virus for treatment of Alzheimer’s disease
Ken Ichiro Fukuchi,Kazuki Tahara,Hong Duck Kim,J. Adam Maxwell,Terry L. Lewis,Mary Ann Accavitti-Loper,Helen Kim,Selvarangan Ponnazhagan,Robert Lalonde +8 more
TL;DR: A novel gene therapy modality where an adeno-associated virus (AAV) encoding anti-Aβ single-chain antibody (scFv) is injected into the corticohippocampal regions of AD mouse models may be a feasible solution for AD without eliciting inflammation.