K
Kazuki Tahara
Researcher at University of Illinois at Chicago
Publications - 6
Citations - 898
Kazuki Tahara is an academic researcher from University of Illinois at Chicago. The author has contributed to research in topics: Microglia & Alzheimer's disease. The author has an hindex of 6, co-authored 6 publications receiving 794 citations. Previous affiliations of Kazuki Tahara include University of Alabama at Birmingham.
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Journal ArticleDOI
Role of toll-like receptor signalling in Aβ uptake and clearance
TL;DR: In this paper, the role of TLR4 in the amyloidogenesis in vivo, determined the amounts of cerebral Abeta in Alzheimer's disease mouse models with different genotypes of TLRs using three distinct methods.
Journal ArticleDOI
TLR4 mutation reduces microglial activation, increases Aβ deposits and exacerbates cognitive deficits in a mouse model of Alzheimer's disease
Min Song,Jing-Ji Jin,Jeong Eun Lim,Jinghong Kou,Abhinandan Pattanayak,Jamaal A. Rehman,Hong Duck Kim,Kazuki Tahara,Robert Lalonde,Robert Lalonde,Ken Ichiro Fukuchi +10 more
TL;DR: The results indicate that TLR4 is not involved in the initiation of Aβ deposition and that, as Aβ deposits start, microglia are activated viaTLR4 signaling to reduce A β deposits and preserve cognitive functions from Aβ-mediated neurotoxicity.
Journal ArticleDOI
Anti-Aβ single chain antibody delivery via adeno-associated virus for treatment of Alzheimer’s disease
Ken Ichiro Fukuchi,Kazuki Tahara,Hong Duck Kim,J. Adam Maxwell,Terry L. Lewis,Mary Ann Accavitti-Loper,Helen Kim,Selvarangan Ponnazhagan,Robert Lalonde +8 more
TL;DR: A novel gene therapy modality where an adeno-associated virus (AAV) encoding anti-Aβ single-chain antibody (scFv) is injected into the corticohippocampal regions of AD mouse models may be a feasible solution for AD without eliciting inflammation.
Journal ArticleDOI
Amelioration of amyloid load by anti-Aβ single-chain antibody in Alzheimer mouse model
Ken Ichiro Fukuchi,Mary Ann Accavitti-Loper,Hong Duck Kim,Hong Duck Kim,Kazuki Tahara,Kazuki Tahara,Yunpeng Cao,Yunpeng Cao,Terry L. Lewis,Robert C Caughey,Helen Kim,Robert Lalonde +11 more
TL;DR: A human single-chain antibody (scFv) library for Abeta immunoreactivity is screened and a scFv that specifically reacts with oligomeric Abeta as well as amyloid plaques in the brain is isolated, which may be useful to treat AD patients without eliciting brain inflammation.
Role of toll-like receptor signalling in Ab uptake and clearance
TL;DR: The role of TLR4 in the amyloidogenesis in vivo was investigated in this article, where the amounts of cerebral Ab in Alzheimer's disease mouse models were determined using three distinct methods: immunocytochemistry, thioflavine-S staining and buffer-soluble and insoluble Ab by ELISA.