H
Honglin Sun
Researcher at Shanghai Jiao Tong University
Publications - 6
Citations - 125
Honglin Sun is an academic researcher from Shanghai Jiao Tong University. The author has contributed to research in topics: Thermogenesis & Adipose tissue. The author has an hindex of 3, co-authored 6 publications receiving 23 citations.
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Journal ArticleDOI
The phytochemical hyperforin triggers thermogenesis in adipose tissue via a Dlat-AMPK signaling axis to curb obesity.
Suzhen Chen,Xiaoxiao Liu,Chao Peng,Chang Tan,Honglin Sun,He Liu,Yao Zhang,Ping Wu,Can Cui,Chuchu Liu,Di Yang,Zhiqiang Li,Junxi Lu,Jian Guan,Xisong Ke,Renxiao Wang,Xiaohai Bo,Xiaojun Xu,Jun-feng Han,Junli Liu +19 more
TL;DR: It is found that phytochemical hyperforin efficiently promoted thermogenesis by stimulating AMPK and PGC-1α via a Ucp1-dependent pathway and indicating that a variation in DLAT is significantly associated with obesity in humans.
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Yin Yang 1 protein ameliorates diabetic nephropathy pathology through transcriptional repression of TGFβ1
Gao Pan,Liliang Li,Liu Yang,Dingkun Gui,Jiarong Zhang,Jun-feng Han,Jiajia Wang,Niansong Wang,Junxi Lu,Suzhen Chen,Liping Hou,Honglin Sun,Liping Xie,Jian Zhou,Chao Peng,Yan Lu,Xuemei Peng,Cunchuan Wang,Ji Miao,Umut Ozcan,Yu Huang,Weiping Jia,Junli Liu +22 more
TL;DR: It is suggested that Yin Yang 1 is a potent transcriptional repressor of TGFB1 during the development of DN in diabetic mice and that small molecules targeting YY1 may serve as promising therapies for treating DN.
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The thermogenic activity of adjacent adipocytes fuels the progression of ccRCC and compromises anti-tumor therapeutic efficacy
Gang Wei,Honglin Sun,Kai Dong,Libing Hu,Qi Wang,Qian Zhuang,Yan Zhu,Xianjing Zhang,Yaodi Shao,Huiru Tang,Zhenfei Li,Suzhen Chen,Junxi Lu,Yibing Wang,Xinxin Gan,Tao P. Zhong,Dingkun Gui,Xiaoyong Hu,Linhui Wang,Junli Liu +19 more
TL;DR: In this article, a bi-directional communication between ccRCC cells and perinephric adipose tissue (PAT) was described, and it was shown that if this cross-communication was short circuited by the pharmacological suppression of adipocyte browning via H89 or KT5720, the anti-tumor efficacy of the TKI, sunitinib, was enhanced.
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Indirubin, a small molecular deriving from connectivity map (CMAP) screening, ameliorates obesity-induced metabolic dysfunction by enhancing brown adipose thermogenesis and white adipose browning
TL;DR: Results clearly show that as an effective BAT (as well as beige cells) activator, indirubin may have a protective effect on the prevention and treatment of obesity and its complications.
Journal ArticleDOI
Inhibition of XBP1s ubiquitination enhances its protein stability and improves glucose homeostasis.
Honglin Sun,Gang Wei,He Liu,Danrui Xiao,Jianbo Huang,Junxi Lu,Ji Miao,Ji Miao,Junli Liu,Suzhen Chen +9 more
TL;DR: The results suggest that delaying the degradation of XBP1s by preventing ubiquitination might provide a strategic approach for reducing ER stress as an anti-diabetes therapy.