H
Hope R. Henderson
Researcher at Brown University
Publications - 5
Citations - 1043
Hope R. Henderson is an academic researcher from Brown University. The author has contributed to research in topics: Palliative care & Gene. The author has an hindex of 5, co-authored 5 publications receiving 962 citations. Previous affiliations of Hope R. Henderson include Boston Children's Hospital & Sanford-Burnham Institute for Medical Research.
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Journal ArticleDOI
Genome-wide mapping of 5-hydroxymethylcytosine in embryonic stem cells
William A. Pastor,Utz Johann Pape,Utz Johann Pape,Yun Huang,Hope R. Henderson,Hope R. Henderson,Ryan Lister,Myunggon Ko,Erin M. McLoughlin,Yevgeny Brudno,Sahasransu Mahapatra,Philipp Kapranov,Mamta Tahiliani,Mamta Tahiliani,George Q. Daley,X. Shirley Liu,Joseph R. Ecker,Patrice M. Milos,Suneet Agarwal,Anjana Rao,Anjana Rao +20 more
TL;DR: The results indicate that 5hmC has a probable role in transcriptional regulation, and suggest a model in which5hmC contributes to the ‘poised’ chromatin signature found at developmentally-regulated genes in ES cells.
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Autophagy-mediated longevity is modulated by lipoprotein biogenesis
Nicole Seah,C. Daniel De Magalhaes Filho,Anna P. Petrashen,Hope R. Henderson,Jade Laguer,Julissa Gonzalez,Andrew Dillin,Malene Hansen,Louis R. Lapierre +8 more
TL;DR: It is found that overexpression of the yolk lipoprotein VIT/vitellogenin reduces the life span of long-lived animals by impairing the induction of autophagy-related and lysosomal genes necessary for longevity.
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Race, treatment preferences, and hospice enrollment: Eligibility criteria may exclude patients with the greatest needs for care
Jessica Fishman,Peter O'Dwyer,Hien L. Lu,Hope R. Henderson,David A. Asch,David A. Asch,David A. Asch,David Casarett,David Casarett,David Casarett +9 more
TL;DR: Whether African‐American patients with cancer are more likely than white patients to have preferences for cancer treatment that exclude them from hospice and whether they are less likely to want specific hospice services is investigated.
Journal ArticleDOI
Structural and Biological Properties of the Drosophila Insulin-like Peptide 5 Show Evolutionary Conservation
Waseem Sajid,Nikolaj Kulahin,Gerd Schluckebier,Ulla Ribel,Hope R. Henderson,Marc Tatar,Bo Falck Hansen,Angela Manegold Svendsen,Vladislav V. Kiselyov,Per Nørgaard,Per-Olof Wahlund,Jakob Brandt,Ronald A. Kohanski,Asser Sloth Andersen,Pierre De Meyts +14 more
TL;DR: The crystal structure of two variants of Drosophila melanogaster insulin-like peptide 5 (DILP5) show high evolutionary conservation of the insulin receptor binding properties despite divergent insulin dimerization mechanisms.
Journal ArticleDOI
Do phase 1 patients have greater needs for palliative care compared with other cancer patients
TL;DR: The objectives of the current study were to define the palliative care needs of phase 1 oncology trial patients and to determine whether their needs are greater than those of other cancer patients.