Hossein Baharvand

TL;DR: This study showed an increase enhancement in neuronal precursor markers and mature neuron markers upon overexpression of Fndc5, concluding that Fnd c5 facilitates neural differentiation.

TL;DR: It is suggested that in vivo specific targeting of astrocytes for forced expression of the miR‐302/367 cluster and VPA administration may increase the brain's potential for repairing myelin insults by the generation of oligodendroglia from astroCytes.

TL;DR: Data have indicated that hESCs primed with Rapa, and induced by a lower concentration of activin A, could lead to DE that had the capability to further differentiate into HLCs and PP cells, but not PE cells.

TL;DR: Investigating the role of the mitochondrial apoptotic pathway and cell energy level during differentiation of mESCs into the cardiomyocytes and their apoptosis suggests that a delay in the release of cytochrome c or delay in ATP increase attenuate apoptosome formation, and caspase activation thereby discriminates apoptosis from differentiation in mEScs.

TL;DR: The data suggest that ESCs can differentiate into functional mature CMs in vitro and may provide an ideal model for the study of cardiomyocytic development and may be useful for cell therapy of various cardiac diseases.