H
Huafei Wang
Researcher at Chinese Academy of Sciences
Publications - 5
Citations - 303
Huafei Wang is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Autophagy & Phosphorylation. The author has an hindex of 5, co-authored 5 publications receiving 207 citations.
Papers
More filters
Journal ArticleDOI
AMPK regulates autophagy by phosphorylating BECN1 at threonine 388
Deyi Zhang,Wei Wang,Xiujie Sun,Daqian Xu,Chenyao Wang,Qian Zhang,Huafei Wang,Wenwen Luo,Yan Chen,Huaiyong Chen,Zhixue Liu +10 more
TL;DR: It is shown that AMP-activated protein kinase (AMPK) regulates autophagy by phosphorylating BECN1 at Thr388, uncovering a novel mechanism of Autophagy regulation.
Journal ArticleDOI
Phosphorylation of ULK1 affects autophagosome fusion and links chaperone-mediated autophagy to macroautophagy
Chenyao Wang,Huafei Wang,Deyi Zhang,Wenwen Luo,Ruilong Liu,Daqian Xu,Lei Diao,Lujian Liao,Zhixue Liu,Zhixue Liu +9 more
TL;DR: A late role for ULK in auotophagosome–lysosome fusion is demonstrated and the significance of the mutual regulation of macroautophagy and CMA in maintaining the balance of autophagy is revealed.
Journal ArticleDOI
Phosphorylation of MITF by AKT affects its downstream targets and causes TP53-dependent cell senescence
Chenyao Wang,Lu Zhao,Qian Su,Xiaoyu Fan,Ying Wang,Shunqiang Gao,Huafei Wang,Huaiyong Chen,Chi Bun Chan,Zhixue Liu +9 more
TL;DR: The findings reveal a mechanism for regulating MITF functions in response to EGF stimulation and suggest a possible implementation for preventing the over proliferation of melanoma cells.
Journal ArticleDOI
The C-ETS2-TFEB Axis Promotes Neuron Survival under Oxidative Stress by Regulating Lysosome Activity
Shumin Ma,Zijun Fang,Wenwen Luo,Yunzhi Yang,Chenyao Wang,Qian Zhang,Huafei Wang,Huaiyong Chen,Chi Bun Chan,Zhixue Liu +9 more
TL;DR: It is shown that cell apoptosis is induced by oxidative stress and that lysosomes play an important role in cell survival under oxidative stress, and it is confirmed that TFEB protects cells from oxidative stress both in vitro and in vivo.
Journal ArticleDOI
miR-27a is highly expressed in H1650 cancer stem cells and regulates proliferation, migration, and invasion.
TL;DR: It is demonstrated that H1650 CD133+ CD34− cells have CSC characteristics and found that miR-27a was highly expressed in H 1650, which may be a potential target for NSCLC therapy.