H
Hugh Rosen
Researcher at Scripps Research Institute
Publications - 233
Citations - 20491
Hugh Rosen is an academic researcher from Scripps Research Institute. The author has contributed to research in topics: Receptor & Agonist. The author has an hindex of 70, co-authored 232 publications receiving 19168 citations. Previous affiliations of Hugh Rosen include Free University of Berlin & National Institutes of Health.
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Journal ArticleDOI
Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists.
Suzanne M. Mandala,Richard Hajdu,James D. Bergstrom,Elizabeth J. Quackenbush,Jenny Xie,James A. Milligan,Rosemary A. Thornton,Gan-Ju Shei,Deborah Card,CarolAnn Keohane,Mark Rosenbach,Jeffrey J. Hale,Christopher L. Lynch,Kathleen M. Rupprecht,William H. Parsons,Hugh Rosen +15 more
TL;DR: It is shown that lymphocyte trafficking is altered by the lysophospholipid sphingosine-1-phosphate (S1P) and by a phosphoryl metabolites of the immunosuppressive agent FTY720.
Journal ArticleDOI
Sphingosine 1-phosphate and its receptors: an autocrine and paracrine network
Hugh Rosen,Edward J. Goetzl +1 more
TL;DR: Recent results that indicate that S1P and its receptors are required for the emigration of thymocytes from the thymus, the trafficking of lymphocytes in secondary lymphoid organs and the migration of B cells into splenic follicles are discussed.
Journal ArticleDOI
Absence of Wallerian Degeneration does not Hinder Regeneration in Peripheral Nerve.
TL;DR: It is found that nerve regeneration in the C57BL/6/Ola mice is not impeded by the presence of largely intact axons in the distal stump and absence of recruited cells, myelin debris and the absence of Schwann cell mitosis.
Journal ArticleDOI
Crystal Structure of a Lipid G Protein–Coupled Receptor
Michael A. Hanson,Christopher B. Roth,Euijung Jo,Mark T. Griffith,Fiona Scott,Greg Reinhart,Hans Desale,Bryan Clemons,Stuart M. Cahalan,Stephan C. Schuerer,M. Germana Sanna,Gye Won Han,Peter Kuhn,Hugh Rosen,Raymond C. Stevens +14 more
TL;DR: The crystal structure of the sphingosine 1-phosphate receptor 1 fused to T4-lysozyme in complex with an antagonist sphingolipid mimic provides a detailed view of the molecular recognition and requirement for hydrophobic volume that activates S1P1, resulting in the modulation of immune and stromal cell responses.
Journal ArticleDOI
Sphingosine 1-Phosphate (S1P) Receptor Subtypes S1P1 and S1P3, Respectively, Regulate Lymphocyte Recirculation and Heart Rate
M. Germana Sanna,Jiayu Liao,Euijung Jo,Christopher Alfonso,Min-Young Ahn,Melissa S. Peterson,Bill Webb,Sophie Lefebvre,Jerold Chun,Nathanael S. Gray,Hugh Rosen +10 more
TL;DR: S 1P1-selective agonists will be of broad utility in understanding cell functions in vitro, and vascular physiology in vivo, and the success of the chemical approach for S1P1 suggests that selective tools for the resolution of function across this broad lipid receptor family are now possible.