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Euijung Jo

Researcher at Scripps Research Institute

Publications -  20
Citations -  3606

Euijung Jo is an academic researcher from Scripps Research Institute. The author has contributed to research in topics: Receptor & Agonist. The author has an hindex of 16, co-authored 20 publications receiving 3438 citations. Previous affiliations of Euijung Jo include College of Osteopathic Medicine of the Pacific & University of Toronto.

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Journal ArticleDOI

Crystal Structure of a Lipid G Protein–Coupled Receptor

TL;DR: The crystal structure of the sphingosine 1-phosphate receptor 1 fused to T4-lysozyme in complex with an antagonist sphingolipid mimic provides a detailed view of the molecular recognition and requirement for hydrophobic volume that activates S1P1, resulting in the modulation of immune and stromal cell responses.
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Sphingosine 1-Phosphate (S1P) Receptor Subtypes S1P1 and S1P3, Respectively, Regulate Lymphocyte Recirculation and Heart Rate

TL;DR: S 1P1-selective agonists will be of broad utility in understanding cell functions in vitro, and vascular physiology in vivo, and the success of the chemical approach for S1P1 suggests that selective tools for the resolution of function across this broad lipid receptor family are now possible.
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α-Synuclein Membrane Interactions and Lipid Specificity

TL;DR: The results suggest that α-Syn membrane interactions are physiologically important and the lipid composition of the cellular membranes may affect these interactions in vivo.
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Sphingosine 1-phosphate type 1 receptor agonism inhibits transendothelial migration of medullary T cells to lymphatic sinuses

TL;DR: Two-photon imaging of living T cells in explanted lymph nodes after treatment with S1P1 agonists or antagonists is provided and results provide visualization of transendothelial migration of T cells into lymphatic sinuses and suggest that S1E2 agonists act mainly on endothelial cell S1p1 receptors to inhibit lymphocyte migration.