S
Stuart M. Cahalan
Researcher at Howard Hughes Medical Institute
Publications - 34
Citations - 4362
Stuart M. Cahalan is an academic researcher from Howard Hughes Medical Institute. The author has contributed to research in topics: Receptor & Mechanotransduction. The author has an hindex of 19, co-authored 34 publications receiving 3420 citations. Previous affiliations of Stuart M. Cahalan include Scripps Research Institute & University of California, San Diego.
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Journal ArticleDOI
Crystal Structure of a Lipid G Protein–Coupled Receptor
Michael A. Hanson,Christopher B. Roth,Euijung Jo,Mark T. Griffith,Fiona Scott,Greg Reinhart,Hans Desale,Bryan Clemons,Stuart M. Cahalan,Stephan C. Schuerer,M. Germana Sanna,Gye Won Han,Peter Kuhn,Hugh Rosen,Raymond C. Stevens +14 more
TL;DR: The crystal structure of the sphingosine 1-phosphate receptor 1 fused to T4-lysozyme in complex with an antagonist sphingolipid mimic provides a detailed view of the molecular recognition and requirement for hydrophobic volume that activates S1P1, resulting in the modulation of immune and stromal cell responses.
Journal ArticleDOI
Piezo1, a mechanically activated ion channel, is required for vascular development in mice
Sanjeev S. Ranade,Zhaozhu Qiu,Seung-Hyun Woo,Sung Sik Hur,Swetha E. Murthy,Stuart M. Cahalan,Jie Xu,Jayanti Mathur,Michael Bandell,Bertrand Coste,Yi Shuan J. Li,Shu Chien,Ardem Patapoutian,Ardem Patapoutian +13 more
TL;DR: It is demonstrated that Piezo1 is activated by shear stress, the major type of mechanical force experienced by endothelial cells in response to blood flow, which suggests a potential role forPiezo1 in mechanotransduction in adult cardiovascular function and disease.
Journal ArticleDOI
Endothelial cells are central orchestrators of cytokine amplification during influenza virus infection
John R. Teijaro,Kevin B. Walsh,Stuart M. Cahalan,Daniel M. Fremgen,Edward Roberts,Fiona Scott,Esther Martinborough,Robert Peach,Michael B. A. Oldstone,Hugh Rosen +9 more
TL;DR: It is demonstrated that suppression of early innate immune responses through S1P1 signaling results in reduced mortality during infection with a human pathogenic strain of influenza virus, suggesting that diseases in which amplification of cytokine storm is a significant pathological component could be chemically tractable.
Journal ArticleDOI
Piezo1 links mechanical forces to red blood cell volume
Stuart M. Cahalan,Viktor Lukacs,Sanjeev S. Ranade,Shu Chien,Michael Bandell,Ardem Patapoutian +5 more
TL;DR: It is shown that RBCs exhibit robust calcium entry in response to mechanical stretch and that this entry is dependent on Piezo1 expression, which plays an essential role in RBC volume homeostasis.
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Dehydrated hereditary stomatocytosis linked to gain-of-function mutations in mechanically activated PIEZO1 ion channels
Juliette Albuisson,Swetha E. Murthy,Michael Bandell,Bertrand Coste,Hélène Louis-Dit-Picard,Hélène Louis-Dit-Picard,Jayanti Mathur,Madeleine Fénéant-Thibault,Gérard Tertian,Jean Pierre De Jaureguiberry,Pierre Yves Syfuss,Stuart M. Cahalan,Loïc Garçon,Fabienne Toutain,Pierre-Simon Rohrlich,Jean Delaunay,Véronique Picard,Xavier Jeunemaitre,Xavier Jeunemaitre,Xavier Jeunemaitre,Ardem Patapoutian,Ardem Patapoutian +21 more
TL;DR: It is found that all PIEZO1 mutations give rise to mechanically activated currents that inactivate more slowly than wild-type currents, providing insight that helps to explain the increased permeability of cations in RBCs of DHS patients.