H
Hugo Lavoie
Researcher at Université de Montréal
Publications - 29
Citations - 2737
Hugo Lavoie is an academic researcher from Université de Montréal. The author has contributed to research in topics: MAPK/ERK pathway & Kinase. The author has an hindex of 22, co-authored 28 publications receiving 2093 citations. Previous affiliations of Hugo Lavoie include Centre Hospitalier Universitaire Sainte-Justine & McGill University.
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Journal ArticleDOI
Regulation of RAF protein kinases in ERK signalling
Hugo Lavoie,Marc Therrien +1 more
TL;DR: The recent discovery that the catalytic activity of RAF depends on an allosteric mechanism driven by kinase domain dimerization is providing a vital new piece of information towards a comprehensive model of RAF function.
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ERK signalling: a master regulator of cell behaviour, life and fate.
TL;DR: The regulation of ERKs, and their control of cell proliferation, cell survival, cell growth, cell metabolism, cell migration and cell differentiation are discussed.
Journal ArticleDOI
Inhibition of RAS function through targeting an allosteric regulatory site
Russell Spencer-Smith,Akiko Koide,Yong Zhou,Raphael R. Eguchi,Fern Sha,Priyanka Gajwani,Dianicha Santana,Ankit Gupta,Ankit Gupta,Miranda Jacobs,Erika Herrero-Garcia,Jacqueline Cobbert,Hugo Lavoie,Matthew J. Smith,Thanashan Rajakulendran,Evan Dowdell,Mustafa Nazir Okur,Irina Dementieva,Frank Sicheri,Frank Sicheri,Marc Therrien,John F. Hancock,Mitsuhiko Ikura,Shohei Koide,Shohei Koide,John P. O'Bryan,John P. O'Bryan +26 more
TL;DR: A functionally critical region, located outside the effector lobe of RAS, that can be targeted for inhibition is described and a previously unrecognized site in RAS is defined for inhibiting RAS function.
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Evolutionary Tinkering with Conserved Components of a Transcriptional Regulatory Network
Hugo Lavoie,Hervé Hogues,Jaideep Mallick,Adnane Sellam,Adnane Sellam,André Nantel,André Nantel,Malcolm Whiteway,Malcolm Whiteway +8 more
TL;DR: A surprising level of evolutionary plasticity is revealed by analysis of differences between related yeasts in the mechanisms regulating the essential cellular process of ribosomal gene expression.
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Inhibitors that stabilize a closed RAF kinase domain conformation induce dimerization.
Hugo Lavoie,Neroshan Thevakumaran,Neroshan Thevakumaran,Gwenaëlle Gavory,John J. Li,John J. Li,Abbas Padeganeh,Sébastien Guiral,Jean Duchaine,Daniel Y.L. Mao,Daniel Y.L. Mao,Michel Bouvier,Frank Sicheri,Frank Sicheri,Marc Therrien +14 more
TL;DR: BRET-based biosensors for the extended RAF family are described, suggesting a model whereby ATP-competitive inhibitors mediate RAF dimerization by stabilizing a rigid closed conformation of the kinase domain.