H
Huige Li
Researcher at University of Mainz
Publications - 172
Citations - 15521
Huige Li is an academic researcher from University of Mainz. The author has contributed to research in topics: Enos & Oxidative stress. The author has an hindex of 60, co-authored 157 publications receiving 13033 citations. Previous affiliations of Huige Li include Central South University.
Papers
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Journal ArticleDOI
Mechanisms Underlying Endothelial Dysfunction in Diabetes Mellitus
Ulrich Hink,Huige Li,Hanke Mollnau,Mathias Oelze,Edi Matheis,Mark Hartmann,Mikhail Skatchkov,Friedrich Thaiss,Rolf A.K. Stahl,Ascan Warnholtz,Thomas Meinertz,Kathy K. Griendling,David G. Harrison,Ulrich Förstermann,Thomas Münzel +14 more
TL;DR: In vivo and in vitro studies have indicated a crucial role of the diacylglycerol-protein kinase C (PKC) pathway in mediatingHyperglycemia is the major causal factor in the development of endothelial dysfunction in patients with diabetes mellitus.
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Roles of Vascular Oxidative Stress and Nitric Oxide in the Pathogenesis of Atherosclerosis
TL;DR: Prevention of vascular oxidative stress and improvement of endothelial NO production represent reasonable therapeutic strategies in addition to the treatment of established risk factors (hypercholesterolemia, hypertension, and diabetes mellitus).
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Effects of Angiotensin II Infusion on the Expression and Function of NAD(P)H Oxidase and Components of Nitric Oxide/cGMP Signaling
Hanke Mollnau,Maria Wendt,Katalin Szöcs,Bernard Lassègue,Eberhard Schulz,Mathias Oelze,Huige Li,Martin Bodenschatz,Michael August,Andrei L. Kleschyov,Nikolaus Tsilimingas,Ulrich Walter,Ulrich Förstermann,Thomas Meinertz,Kathy K. Griendling,Thomas Münzel +15 more
TL;DR: It is concluded that angiotensin II-induced increases in the activity and the expression of NAD(P)H oxidase are at least in part PKC-dependent and may trigger NOS III uncoupling, leading to impaired NO/cGMP signaling and to endothelial dysfunction in this animal model.
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Resveratrol, a Polyphenolic Phytoalexin Present in Red Wine, Enhances Expression and Activity of Endothelial Nitric Oxide Synthase
Thomas Wallerath,Göran Deckert,Thomas Ternes,Henrik Anderson,Huige Li,Klaus Witte,Ulrich Förstermann +6 more
TL;DR: In concert with other effects, the stimulation of eNOS expression and activity may contribute to the cardiovascular protective effects attributed to resveratrol.
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Nitric oxide in the pathogenesis of vascular disease
Huige Li,Ulrich Förstermann +1 more
TL;DR: In cerebrovascular stroke, neuronal NOS I and cytokine‐inducible NOS II play a key role in neurodegeneration, whereas endothelial NOS III is important for maintaining cerebral blood flow and preventing neuronal injury.