H
Huiling He
Researcher at Ohio State University
Publications - 43
Citations - 3055
Huiling He is an academic researcher from Ohio State University. The author has contributed to research in topics: Thyroid cancer & Thyroid carcinoma. The author has an hindex of 23, co-authored 43 publications receiving 2634 citations. Previous affiliations of Huiling He include The Ohio State University Wexner Medical Center.
Papers
More filters
Journal ArticleDOI
Common variants on 9q22.33 and 14q13.3 predispose to thyroid cancer in European populations
Julius Gudmundsson,Patrick Sulem,Daniel F. Gudbjartsson,Jon G. Jonasson,Asgeir Sigurdsson,Jon Thor Bergthorsson,Huiling He,Thorarinn Blondal,Frank Geller,Margret Jakobsdottir,Droplaug N Magnusdottir,Sigurborg Matthiasdottir,Simon N. Stacey,Oskar B Skarphedinsson,Hafdis T. Helgadottir,W. G. Li,Rebecca Nagy,Esperanza Aguillo,Eduardo Faure,Enrique Prats,Berta Saez,Mariano Martinez,Gudmundur I. Eyjolfsson,Unnur S. Bjornsdottir,Hilma Holm,Hilma Holm,Kristleifur Kristjansson,Michael L. Frigge,Hoskuldur Kristvinsson,Jeffrey R. Gulcher,Thorvaldur Jonsson,Thorunn Rafnar,Hannes Hjartarsson,Jose I. Mayordomo,Albert de la Chapelle,Jon Hrafnkelsson,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Augustine Kong,Kari Stefansson,Kari Stefansson +40 more
TL;DR: Two common variants, located on 9q22.33 and 14q13.3, are shown to be associated with thyroid cancer, and both risk alleles are associated with low concentrations of thyroid stimulating hormone (TSH) and high concentration of triiodothyronine (T3).
Journal ArticleDOI
Gene expression and functional evidence of epithelial-to-mesenchymal transition in papillary thyroid carcinoma invasion
Vasily Vasko,Allan V. Espinosa,William T. Scouten,Huiling He,Herbert Auer,Herbert Auer,Sandya Liyanarachchi,Alexander Larin,Victoria Savchenko,Gary L. Francis,Gary L. Francis,Albert de la Chapelle,Motoyasu Saji,Matthew D. Ringel +13 more
TL;DR: It is concluded that EMT is common in PTC invasion and that vimentin regulates thyroid cancer EMT in vitro, and that Vimentin was required both for the development and maintenance of a mesenchymal morphology and invasiveness in thyroid cancer cells.
Journal ArticleDOI
Mutations in U4atac snRNA, a Component of the Minor Spliceosome, in the Developmental Disorder MOPD I
Huiling He,Sandya Liyanarachchi,Keiko Akagi,Rebecca Nagy,Jingfeng Li,Rosemary C. Dietrich,W. G. Li,Nikhil Sebastian,Bernard Wen,Baozhong Xin,Jarnail Singh,Pearlly S. Yan,Hansjuerg Alder,Eric Haan,Eric Haan,Dagmar Wieczorek,Beate Albrecht,Erik G. Puffenberger,Heng Wang,Judith A. Westman,Richard A. Padgett,David E. Symer,Albert de la Chapelle +22 more
TL;DR: It is shown that a gene encoding U4atac snRNA, a component of the minor U12-dependent spliceosome, is mutated in individuals with microcephalic osteodysplastic primordial dwarfism type I, a severe developmental disorder characterized by extreme intrauterine growth retardation and multiple organ abnormalities.
Journal ArticleDOI
The polymorphism rs944289 predisposes to papillary thyroid carcinoma through a large intergenic noncoding RNA gene of tumor suppressor type
Jarosław Jendrzejewski,Huiling He,Hanna S. Radomska,W. G. Li,Jerneja Tomsic,Sandya Liyanarachchi,Ramana V. Davuluri,Rebecca Nagy,Albert de la Chapelle +8 more
TL;DR: The data suggest that SNP rs944289 predisposes to PTC through a previously uncharacterized, long intergenic noncoding RNA gene (PTCSC3) that has the characteristics of a tumor suppressor.
Journal ArticleDOI
Discovery of common variants associated with low TSH levels and thyroid cancer risk
Julius Gudmundsson,Patrick Sulem,Daniel F. Gudbjartsson,Jon G. Jonasson,Gisli Masson,Huiling He,Aslaug Jonasdottir,Asgeir Sigurdsson,Simon N. Stacey,Hrefna Johannsdottir,Hafdis T. Helgadottir,W. G. Li,Rebecca Nagy,Matthew D. Ringel,Richard T. Kloos,Marieke de Visser,Theo S. Plantinga,Martin den Heijer,Esperanza Aguillo,Angeles Panadero,Enrique Prats,Almudena García-Castaño,Ana de Juan,Fernando Rivera,G. Bragi Walters,Hjordis Bjarnason,Laufey Tryggvadottir,Gudmundur I. Eyjolfsson,Unnur S. Bjornsdottir,Hilma Holm,Isleifur Olafsson,Kristleifur Kristjansson,Hoskuldur Kristvinsson,Olafur T. Magnusson,Gudmar Thorleifsson,Jeffrey R. Gulcher,Augustine Kong,Lambertus A. Kiemeney,Thorvaldur Jonsson,Hannes Hjartarson,Jose I. Mayordomo,Romana T. Netea-Maier,Albert de la Chapelle,Jon Hrafnkelsson,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Thorunn Rafnar,Kari Stefansson,Kari Stefansson +48 more
TL;DR: To search for sequence variants conferring risk of nonmedullary thyroid cancer, analysis on 22 SNPs with a P < 5 × 10−8 in a genome-wide association study on levels of thyroid stimulating hormone in 27,758 Icelanders focused on rs965513, a region previously reported to contain an uncorrelated variant conferringrisk of thyroid cancer.