Hafdis T. Helgadottir

TL;DR: A genome-wide association scan for sequence variants affecting eosinophil counts in blood of 9,392 Icelanders found that a nonsynonymous SNP at 12q24, in SH2B3, associated significantly with myocardial infarction in six different populations.

TL;DR: It is found that rs401681[C] on chromosome 5p15 satisfied the threshold for genome-wide significance and seems to confer protection against cutaneous melanoma, and investigation of the region led to rs2736098[A], which showed stronger association with some cancer types, but neither variant could fully account for the association of the other.

TL;DR: Two common variants, located on 9q22.33 and 14q13.3, are shown to be associated with thyroid cancer, and both risk alleles are associated with low concentrations of thyroid stimulating hormone (TSH) and high concentration of triiodothyronine (T3).

TL;DR: Ovarian tumors from heterozygous carriers of the Icelandic mutation show loss of the wild-type allele, indicating that BRIP1 behaves like a classical tumor suppressor gene in ovarian cancer.

TL;DR: A previously unidentified sick sinus syndrome susceptibility gene, MYH6, encoding the alpha heavy chain subunit of cardiac myosin is discovered through complementary application of SNP genotyping, whole-genome sequencing and imputation in 38,384 Icelanders.