H
Huiyan Li
Researcher at Sun Yat-sen University
Publications - 12
Citations - 374
Huiyan Li is an academic researcher from Sun Yat-sen University. The author has contributed to research in topics: Apoptosis & Peritoneal dialysis. The author has an hindex of 7, co-authored 9 publications receiving 209 citations.
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Journal ArticleDOI
Atg5-mediated autophagy deficiency in proximal tubules promotes cell cycle G2/M arrest and renal fibrosis.
Huiyan Li,Xuan Peng,Yating Wang,Shirong Cao,Liping Xiong,Jinjin Fan,Yihan Wang,Shougang Zhuang,Xueqing Yu,Haiping Mao +9 more
TL;DR: Atg5-mediated autophagy in proximal epithelial cells is a critical host-defense mechanism that prevents renal fibrosis by blocking G2/M arrest, suggesting the regulation of cell cycle progression by ATG5 is Autophagy dependent.
Journal ArticleDOI
ATG5-mediated autophagy suppresses NF-κB signaling to limit epithelial inflammatory response to kidney injury
TL;DR: ABlation of epithelial ATG5 genes markedly impaired autophagy, resulting in enhanced nuclear factor κB (NF-κB) activation, macrophage and lymphocyte infiltration, and proinflammatory cytokines production in obstructed kidneys, as compared with wild-type mice.
Journal ArticleDOI
Drp1-mediated mitochondrial fission promotes renal fibroblast activation and fibrogenesis.
Yating Wang,Miaoqing Lu,Liping Xiong,Jinjin Fan,Yi Zhou,Huiyan Li,Xuan Peng,Zhong Zhong,Yihan Wang,Fengxian Huang,Wei Chen,Xueqing Yu,Haiping Mao +12 more
TL;DR: The results imply that inhibiting p-Drp1S616-mediated mitochondrial fission attenuates fibroblast activation and proliferation in renal fibrosis through epigenetic regulation of fibrosis-related genes transcription and may serve as a therapeutic target for retarding progression of chronic kidney disease.
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Serum Potassium Levels and Its Variability in Incident Peritoneal Dialysis Patients: Associations with Mortality
Qingdong Xu,Fenghua Xu,Li Fan,Liping Xiong,Huiyan Li,Shirong Cao,Xiaoyan Lin,Zhihua Zheng,Xueqing Yu,Haiping Mao +9 more
TL;DR: A lower serum potassium level was associated with all-cause and cardiovascular mortality during the first year of follow-up in incident PD patients and higher variability of serum potassium levels conferred an increased risk of death in this population of patients.
Journal ArticleDOI
Association of Pulmonary Hypertension with Mortality in Incident Peritoneal Dialysis Patients.
Qingdong Xu,Liping Xiong,Li Fan,Fenghua Xu,Yan Yang,Huiyan Li,Xuan Peng,Shirong Cao,Zhi-Hua Zheng,Xiao Yang,Xueqing Yu,Haiping Mao +11 more
TL;DR: The prevalence of pulmonary hypertension at the start of peritoneal dialysis was common and associated with increased risk of both all-cause and cardiovascular mortality in incident PD patients.