Z
Zhong Zhong
Researcher at Sun Yat-sen University
Publications - 28
Citations - 244
Zhong Zhong is an academic researcher from Sun Yat-sen University. The author has contributed to research in topics: Medicine & Peritoneal dialysis. The author has an hindex of 7, co-authored 21 publications receiving 122 citations.
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Journal ArticleDOI
Drp1-mediated mitochondrial fission promotes renal fibroblast activation and fibrogenesis.
Yating Wang,Miaoqing Lu,Liping Xiong,Jinjin Fan,Yi Zhou,Huiyan Li,Xuan Peng,Zhong Zhong,Yihan Wang,Fengxian Huang,Wei Chen,Xueqing Yu,Haiping Mao +12 more
TL;DR: The results imply that inhibiting p-Drp1S616-mediated mitochondrial fission attenuates fibroblast activation and proliferation in renal fibrosis through epigenetic regulation of fibrosis-related genes transcription and may serve as a therapeutic target for retarding progression of chronic kidney disease.
Journal ArticleDOI
An increasing of red blood cell distribution width was associated with cardiovascular mortality in patients on peritoneal dialysis
Fenfen Peng,Zhijian Li,Zhong Zhong,Qimei Luo,Qunying Guo,Fengxian Huang,Xueqing Yu,Xiao Yang +7 more
Journal ArticleDOI
Low α-defensin gene copy number increases the risk for IgA nephropathy and renal dysfunction
Zhen Ai,Ming Li,Wenting Liu,Jia Nee Foo,Omniah Mansouri,Peiran Yin,Qian Zhou,Xueqing Tang,Xiuqing Dong,Shaozhen Feng,Ricong Xu,Zhong Zhong,Jian Chen,Jianxin Wan,Tanqi Lou,Jianwen Yu,Qin Zhou,Jinjin Fan,Haiping Mao,Daniel P. Gale,Jonathan Barratt,John A.L. Armour,Jianjun Liu,Jianjun Liu,Jianjun Liu,Xueqing Yu +25 more
TL;DR: Investigation in Chinese patients with IgA nephropathy and healthy controls shows that low copy number of the α-defensin gene increased the risk for IgAN development and renal degeneration, and the DEFA1A3 CNV locus may be a potential therapeutic target in IgAN.
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Genome-Wide Meta-Analysis Identifies Three Novel Susceptibility Loci and Reveals Ethnic Heterogeneity of Genetic Susceptibility for IgA Nephropathy.
Ming Li,Ling Wang,Dianchun Shi,Jia Nee Foo,Jia Nee Foo,Zhong Zhong,Chiea Chuen Khor,Chiara Lanzani,Lorena Citterio,Erika Salvi,Peiran Yin,Jin-Xin Bei,Li Wang,Yunhua Liao,Jian Chen,Qinkai Chen,Gang Xu,Gengru Jiang,Jianxin Wan,Meng-Hua Chen,Nan Chen,Hong Zhang,Yi Xin Zeng,Zhihong Liu,Jianjun Liu,Jianjun Liu,Xueqing Yu +26 more
TL;DR: A meta-analysis of GWAS data revealed three novel genetic risk loci for IgAN, and three HLA polymorphisms and two SNPs within the MHC region, and demonstrated the genetic heterogeneity of seven loci out of 24 confirmed risk SNPs.
Journal ArticleDOI
Association Analysis of the MHC in Lupus Nephritis.
Ricong Xu,Ricong Xu,Qibin Li,Rongjun Liu,Juan Shen,Ming Li,Ming-Hui Zhao,Meng Wang,Qijun Liao,Haiping Mao,Zhijian Li,Na Zhou,Peiran Yin,Li Yue,Xueqing Tang,Tian Wu,Zhong Zhong,Yan Wang,Zhen Ai,Ou Wang,Nan Chen,Xiaoqin Yang,Junbin Fang,Ping Fu,Jieruo Gu,Kun Ye,Jian Chen,Lie Dai,Huafeng Liu,Zhangsuo Liu,Yunhua Liao,Jianxin Wan,Guohua Ding,Jinghong Zhao,Hao Zhang,Shuxia Fu,Liangdan Sun,Xuejun Zhang,Xuejun Zhang,Huanming Yang,Jian Wang,Jun Wang,Jun Wang,Jianjun Liu,Jianjun Liu,Yingrui Li,Xueqing Yu +46 more
TL;DR: Data from a comprehensive sequencing analysis of the whole MHC region implicate aberrant peptide presentation by MHC classes 1 and 2 molecules and sex hormone modulation in the development of LN.