Hyun-Dong Chang

TL;DR: Diversity measures obtained from both methods were correlated and captured identical trends in microbial community structures, finding no difference in patients’ pretreatment alpha or beta diversity compared to healthy controls and a significant and progressive loss of alpha diversity during chemoimmunotherapy.

TL;DR: A quantitative model of plasma cell survival is generated based on flow-cytometric quantification of key signaling proteins in the presence or absence of the survival signals APRIL and contact to the stromal cell line ST2 and highlights a requirement for differential regulation of individual caspases.

TL;DR: The results showing less disease severity in a transfer model of OVA-induced arthritis open a new therapeutic avenue for the control of unwanted T helper cell expansion in immune-mediated diseases by antagomirs.

TL;DR: The basic mechanisms involved in the generation and maintenance of Immunological memory, as well as the implications of immunological memory for the pathogenesis and therapy of rheumatic diseases, cancer and vaccine development are discussed.

TL;DR: The bone marrow is increasingly recognized as a fundamental component of long-lasting immunological memory, not only providing protective immunity but also fuelling chronic inflammation as discussed by the authors , and it has been shown that the bone marrow functions as the "backbone" of immunologic memory, hosting the memory plasma cells which provide not only humoral immunity, but also memory B and T cells, which constitute reactive memory.