H
Hyun-Dong Chang
Researcher at Leibniz Association
Publications - 96
Citations - 6463
Hyun-Dong Chang is an academic researcher from Leibniz Association. The author has contributed to research in topics: Bone marrow & Immune system. The author has an hindex of 33, co-authored 84 publications receiving 5401 citations.
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Journal ArticleDOI
Persistence of effector memory Th1 cells is regulated by Hopx
Inka Albrecht,Uwe Niesner,Marko Janke,Astrid Menning,Christoph Loddenkemper,Anja A. Kühl,Inga Lepenies,Maria H. Lexberg,Kerstin Westendorf,Kristyna Hradilkova,Joachim R. Grün,Alf Hamann,Jonathan A. Epstein,Hyun-Dong Chang,Koji Tokoyoda,Andreas Radbruch +15 more
TL;DR: In murine Th1 cells, Hopx regulates the expression of genes involved in regulation of apoptosis and survival and makes them refractory to Fas‐induced apoptosis, demonstrating a key role of Hopx for Th1‐mediated immunopathology.
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IL-1β and TGF-β Act Antagonistically in Induction and Differentially in Propagation of Human Proinflammatory Precursor CD4+ T Cells
Katrin Hebel,Marion Rudolph,Bernhard Kosak,Hyun-Dong Chang,Jana Butzmann,Monika C. Brunner-Weinzierl +5 more
TL;DR: It is proposed that IL-1β induces a general proinflammatory Th cell precursor that, in the presence of the lineage-specifying cytokines, further differentiates into one of the specific Th cell subpopulations.
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Nitric oxide enhances Th9 cell differentiation and airway inflammation
Wanda Niedbala,Anne-Gaelle Besnard,Daniele C. Nascimento,Paula B. Donate,Fabiane Sônego,Edwin Yip,Rodrigo Guabiraba,Hyun-Dong Chang,Sandra Y. Fukada,Robert J. Salmond,Edgar Schmitt,Tobias Bopp,Bernhard Ryffel,Foo Y. Liew +13 more
TL;DR: It is shown that nitric oxide promotes Th9 cell polarization of murine and human CD4+ T cells and provides a hitherto unrecognized mechanism for NO-mediated airway inflammation via the expansion of Th9 cells.
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Longitudinal intravital imaging of the femoral bone marrow reveals plasticity within marrow vasculature
David Reismann,Jonathan Stefanowski,Jonathan Stefanowski,Robert Günther,Asylkhan Rakhymzhan,Romano Matthys,Reto Nützi,Sandra Zehentmeier,Sandra Zehentmeier,Sandra Zehentmeier,Katharina Schmidt-Bleek,Georg Petkau,Hyun-Dong Chang,Sandra Naundorf,York Winter,Fritz Melchers,Georg N. Duda,Anja E. Hauser,Anja E. Hauser,Raluca Niesner +19 more
TL;DR: A microendoscopic multi-photon imaging approach called LIMB (longitudinal intravital imaging of the bone marrow) is developed to analyze cellular dynamics within the deep marrow and reveals extensive vascular plasticity within the marrow during bone healing and steady-state homeostasis.
Journal ArticleDOI
High-resolution microbiota flow cytometry reveals dynamic colitis-associated changes in fecal bacterial composition.
Jakob Zimmermann,Thomas Hübschmann,Florian Schattenberg,Joachim Schumann,Pawel Durek,René Riedel,Marie Friedrich,Rainer Glauben,Britta Siegmund,Andreas Radbruch,Susann Müller,Hyun-Dong Chang +11 more
TL;DR: Using high‐resolution flow cytometry of bacterial shape (forward scatter) and DNA content (DAPI staining), this innovative method provides a fast and inexpensive tool to interrogate the microbiota on the single‐cell level.