Hyun-Dong Chang

TL;DR: These findings define murine and human regulatory B cells as an epigenetically controlled functional state of mature B cell subsets and open a new perspective on IL‐10 regulation in B cells in homeostasis and disease.

TL;DR: Recent findings are discussed along with interpretations and comments that may help to resolve the existing puzzles and should open new avenues of investigation about the biochemical nature of FcµR.

TL;DR: The explosion of microbial profiling became possible by the development of deep-sequencing methods, often called next generation sequencing (NGS), which happened around the year 2008 and requires bioinformatics expertise and sophisticated tools to decipher, analyze, sort, and present the data.

TL;DR: The heterogeneity of synovial T lymphocytes in JIA patients is dissected by single cell RNA-sequencing to point out that multiple types of T lymphocyte have to be targeted for therapeutic regeneration of tolerance in arthritis.

TL;DR: The molecular basis of the persistence of experienced T lymphocytes, also known as "memory T lymphocyte," is still enigmatic as discussed by the authors, and the authors are beginning to understand their considerable heterogeneity and topographic compartmentalization into memory T cells circulating through the body and those residing in a particular tissue.