Bioactivity-guided isolation of ginsenosides from Korean Red Ginseng with cytotoxic activity against human lung adenocarcinoma cells.
Jae Sik Yu,Hyun-Soo Roh,Kwan-Hyuck Baek,Seul Lee,Sil Kim,Hae Min So,Eunjung Moon,Changhyun Pang,Tae Su Jang,Ki-Hyun Kim +9 more
TLDR
Bioactivity-guided fractionation of the KRG extract revealed that its ethyl acetate–soluble fraction exerts significant cytotoxic activity against all human lung cancer cell lines tested by inducing apoptosis, providing experimental evidence for a novel biological activity of ginsenoside Rg3 againsthuman lung cancer cells.About:
This article is published in Journal of Ginseng Research.The article was published on 2018-10-01 and is currently open access. It has received 56 citations till now. The article focuses on the topics: Ginsenoside & Ginseng.read more
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Pharmacological potential of ginseng and its major component ginsenosides
Zubair Ahmed Ratan,Mohammad Faisal Haidere,Yo Han Hong,Sang Hee Park,Jeong-Oog Lee,Jongsung Lee,Jae Youl Cho +6 more
TL;DR: Ginseng could be a valuable resource for future drug development; however, further higher quality evidence is required as it may have drug interactions although the available evidence suggests it is a relatively safe product.
Journal ArticleDOI
Modulation of Autophagy for Controlling Immunity
TL;DR: The therapeutic potential of autophagy modulators that can impact immune responses and the mechanisms of action responsible are highlighted.
Journal ArticleDOI
Suppression of 6-Hydroxydopamine-Induced Oxidative Stress by Hyperoside Via Activation of Nrf2/HO-1 Signaling in Dopaminergic Neurons
Seung-Hwan Kwon,Seoung Rak Lee,Yong Joo Park,Moonjin Ra,Yongjun Lee,Changhyun Pang,Ki-Hyun Kim +6 more
TL;DR: Hyperoside, via the induction of Nrf2-dependent HO-1 activation, suppresses neuronal death caused by 6-OHDA-induced oxidative stress, and represents a potential preventive and therapeutic target in Parkinson′s disease management.
Journal ArticleDOI
Antifungal Phenols from Woodfordia uniflora Collected in Oman
TL;DR: Phytochemical screening of the extract of W. uniflora found three new phenolic compounds, including woodfordiamycin, woodfordic acid, and rhamnetin 3-O-(6″-galloyl)-β-d-glucopyranoside, which showed antifungal activity against human fungal pathogens Cryptococcus neoformans and Candida albicans.
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Herqueilenone A, a unique rearranged benzoquinone-chromanone from the Hawaiian volcanic soil-associated fungal strain Penicillium herquei FT729.
Jae Sik Yu,Chun-Shun Li,Mincheol Kwon,Taehoon Oh,Tae Hyun Lee,Dong Hyun Kim,Jong Seog Ahn,Sung-Kyun Ko,Chung Sub Kim,Shugeng Cao,Ki-Hyun Kim +10 more
TL;DR: The study of a Hawaiian volcanic soil-associated fungal strain Penicillium herquei FT729 led to the isolation of one unprecedented benzoquinone-chromanone, herqueilenone A and two phenalenone derivatives, whose structures were determined through extensive analysis of NMR spectroscopic data and gauge-including atomic orbital (GIAO) NMR chemical shifts and ECD calculations.
References
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Apoptosis: A Review of Programmed Cell Death
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Specific Proteolytic Cleavage of Poly(ADP-ribose) Polymerase: An Early Marker of Chemotherapy-induced Apoptosis
TL;DR: The results suggest that proteolytic cleavage of pADPRp, in addition to being an early marker of chemotherapy-induced apoptosis, might reflect more widespread proteolysis that is a critical biochemical event early during the process of physiological cell death.
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Molecular origins of cancer: Lung cancer
TL;DR: From the Departments of Thoracic/Head and Neck Medical Oncology and Clinical Cancer Prevention, University of Texas M.D. Anderson Cancer Center, Houston.
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Apoptosis-inducing factor is involved in the regulation of caspase-independent neuronal cell death
Sean P. Cregan,Andre Fortin,Jason G. MacLaurin,Steven M. Callaghan,Francesco Cecconi,Seong-Woon Yu,Ted M. Dawson,Valina L. Dawson,David S. Park,Guido Kroemer,Ruth S. Slack +10 more
TL;DR: It is demonstrated that p53 can induce neuronal cell death via a caspase-mediated process activated by apoptotic activating factor-1 (Apaf1) and via a delayed onset casp enzyme-independent mechanism, and that apoptosis-inducing factor (AIF) is an important factor involved in the regulation of this caspases-independent neuronal cellDeath.