H
Hyung Chan Suh
Researcher at Science Applications International Corporation
Publications - 9
Citations - 582
Hyung Chan Suh is an academic researcher from Science Applications International Corporation. The author has contributed to research in topics: Haematopoiesis & Cellular differentiation. The author has an hindex of 8, co-authored 9 publications receiving 545 citations. Previous affiliations of Hyung Chan Suh include Leidos.
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Journal ArticleDOI
Combined Loss of Cdk2 and Cdk4 Results in Embryonic Lethality and Rb Hypophosphorylation
Cyril Berthet,Kimberly D. Klarmann,Mary Beth Hilton,Hyung Chan Suh,Jonathan R. Keller,Hiroaki Kiyokawa,Philipp Kaldis +6 more
TL;DR: It is demonstrated that Cdk2 and Cdk4 cooperate to phosphorylate Rb in vivo and to couple the G1/S phase transition to mitosis via E2F-dependent regulation of gene expression.
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C/EBPα deficiency results in hyperproliferation of hematopoietic progenitor cells and disrupts macrophage development in vitro and in vivo
Victoria Heath,Hyung Chan Suh,Matthew Holman,Katie Renn,John Gooya,Sarah Parkin,Kimberly D. Klarmann,Mariaestela Ortiz,Peter Johnson,Jonathan R. Keller +9 more
TL;DR: It is demonstrated that C/EBPalpha(-/-) fetal liver (FL) progenitors are hyperproliferative, show decreased differentiation potential, and show increased self-renewal capacity in response to hematopoietic growth factors (HGFs).
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C/EBPα determines hematopoietic cell fate in multipotential progenitor cells by inhibiting erythroid differentiation and inducing myeloid differentiation
Hyung Chan Suh,John Gooya,John Gooya,Katie Renn,Katie Renn,Alan D. Friedman,Alan D. Friedman,Peter F. Johnson,Peter F. Johnson,Jonathan R. Keller,Jonathan R. Keller +10 more
TL;DR: C/EBPalpha functions in hematopoietic cell fate decisions by the dual actions of inhibiting erythroid and inducing myeloid gene expression in multipotential progenitors.
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Id2 intrinsically regulates lymphoid and erythroid development via interaction with different target proteins.
TL;DR: The data identified Id2 as a physiologically relevant regulator of E2A during B lymphopoiesis and identified a novel Id2 function in erythroid development, which concludes that Id2 regulates lymphoid and erystroid development via interaction with different target proteins.
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The folliculin-FNIP1 pathway deleted in human Birt-Hogg-Dubé syndrome is required for murine B-cell development
Masaya Baba,Jonathan R. Keller,Hong-Wei Sun,Wolfgang Resch,Stefan Kuchen,Hyung Chan Suh,Hisashi Hasumi,Yukiko Hasumi,Kyong-Rim Kieffer-Kwon,Carme Gallego Gonzalez,Robert M. Hughes,Mara E. Klein,HyoungBin Oh,Paul W Bible,Eileen Southon,Lino Tessarollo,Laura S. Schmidt,Laura S. Schmidt,W. Marston Linehan,Rafael Casellas +19 more
TL;DR: It is demonstrated that the FLCN-FNIP complex deregulated in BHD syndrome is absolutely required for B-cell differentiation, and that it functions through both mTOR-dependent and independent pathways.