J
John Gooya
Researcher at Science Applications International Corporation
Publications - 21
Citations - 906
John Gooya is an academic researcher from Science Applications International Corporation. The author has contributed to research in topics: Progenitor cell & Haematopoiesis. The author has an hindex of 17, co-authored 21 publications receiving 872 citations. Previous affiliations of John Gooya include MedImmune.
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Journal ArticleDOI
A human antibody-drug conjugate targeting EphA2 inhibits tumor growth in vivo.
Dowdy Jackson,John Gooya,Shenlan Mao,Krista Kinneer,Linda Xu,Margarita Camara,Christine Fazenbaker,Ryan Fleming,Sudha Swamynathan,Damon L. Meyer,Peter D. Senter,Changshou Gao,Herren Wu,Michael S. Kinch,Steven Coats,Peter A. Kiener,David A. Tice +16 more
TL;DR: The isolation and characterization of a fully human monoclonal antibody (1C1) that selectively binds both the human and rodent EphA2 receptor is described and data support the use of an antibody-drug conjugate approach to selectively target and inhibit the growth of E phA2-expressing tumors.
Journal ArticleDOI
C/EBPα deficiency results in hyperproliferation of hematopoietic progenitor cells and disrupts macrophage development in vitro and in vivo
Victoria Heath,Hyung Chan Suh,Matthew Holman,Katie Renn,John Gooya,Sarah Parkin,Kimberly D. Klarmann,Mariaestela Ortiz,Peter Johnson,Jonathan R. Keller +9 more
TL;DR: It is demonstrated that C/EBPalpha(-/-) fetal liver (FL) progenitors are hyperproliferative, show decreased differentiation potential, and show increased self-renewal capacity in response to hematopoietic growth factors (HGFs).
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EphA2 Immunoconjugate as Molecularly Targeted Chemotherapy for Ovarian Carcinoma
Jeong Won Lee,Hee Dong Han,Mian M.K. Shahzad,Mian M.K. Shahzad,Seung Wook Kim,Lingegowda S. Mangala,Alpa M. Nick,Chunhua Lu,Robert R. Langley,Rosemarie Schmandt,Hye Sun Kim,Hye Sun Kim,Shenlan Mao,John Gooya,Christine Fazenbaker,Dowdy Jackson,David A. Tice,Charles N. Landen,Robert L. Coleman,Anil K. Sood +19 more
TL;DR: The 1C1-mcMMAF immunoconjugate had antitumor activity in preclinical models of ovarian carcinoma and caused regression of established tumors and increased survival of the mice.
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Distinct and overlapping direct effects of macrophage inflammatory protein-1 alpha and transforming growth factor beta on hematopoietic progenitor/stem cell growth
Jonathan R. Keller,Stephen H. Bartelmez,Ewa Sitnicka,Francis W. Ruscetti,Mariaestella Ortiz,John Gooya,Sten Eirik W. Jacobsen +6 more
TL;DR: MIP-1 alpha and TGF beta are direct bidirectional regulators of HPC growth, whose effects are dependent on other growth factors present as well as the maturational state of the HPC assayed.
Journal ArticleDOI
EphA2 Targeted Chemotherapy Using an Antibody Drug Conjugate in Endometrial Carcinoma
Jeong Won Lee,Rebecca L. Stone,Sun Joo Lee,Sun Joo Lee,Eun Ji Nam,Eun Ji Nam,Ju Won Roh,Ju Won Roh,Alpa M. Nick,Hee Dong Han,Mian M.K. Shahzad,Mian M.K. Shahzad,Hye Sun Kim,Hye Sun Kim,Lingegowda S. Mangala,Nicholas B. Jennings,Shenlan Mao,John Gooya,Dowdy Jackson,Robert L. Coleman,Anil K. Sood +20 more
TL;DR: The preclinical data for endometrial cancer treatment using MEDI-547 show substantial antitumor activity related to decreased proliferation and increased apoptosis of tumor and associated endothelial cells.